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| Survivin expression in bladder carcinoma and its relationship to the blood flow of CPA |
| JIN Rong, LI Yan-min, WANG Zhong, JIAO Tong |
| The First Central Hospital of Tianjin, Tianjin 300194, China |
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Abstract Objective: To evaluate the relationship between the expression of Survivin gene protein and the blood flow of color power Doppler angio imaging(CPA) in bladder carcinoma. Methods: Fifty patients of bladder carcinoma and 20 cases of hyperplasia were examined preoperatively by CPA whereas Survivin gene protein was stained immunohistochemistry after operation. Results: The positive expression ratio of Survivin gene protein in 50 cases of bladder carcinoma(78%) was significant higher than that of the hyperplasia group(25%, P<0.05). The expression intensity of Survivin gene in the group of bladder carcinoma correlated positively to the degreens of their CPA(r=0.699, P<0.05). The resistance index(RI) value of malignant group(0.50±0.43) was slight lower than that of the hyperplasia group(0.69±0.41, P<0.05). In addition, the expression intensity of Survivin gene in the group of bladder carcinoma correlated negatively to their RI values(r=-0.545, P<0.05). Conclusion: The high expression of Survivin gene was widely observed in bladder carcinoma, and its expression intensity correlated positively to the RI values. The combination of Survivin gene and CPA can help us to assess the bladder carcinoma before and after operation. Furthermore, it may provide important information for earlier clinical diagnosis and judgment of prognosis.
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Received: 24 August 2006
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2007, Vol. 18 
