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| Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas |
| ZHANG Yi-nian, HE Ning, ZHOU Jun-lin |
| Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730030, China |
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Abstract Objective: To investigate the correlation between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer(EMMPRIN) and Galectin-3 in pituitary adenomas. Methods: MRI was performed preoperatively in 34 patients with histologically verified pituitary adenomas, EMMPRIN and Galectin-3 expression were determined by immunohistochemical SP method in all patients. The correlation between expression of determined proteins and MRI features between invasive and non-invasive pituitary adenomas were studied. Results: Among MRI invasive features, Knosp score, Cottier score, irregular tumor shape and bilateral intracavernous carotid artery asymmetry correlated with increased expression of EMMPRIN and Galectin-3(P<0.05). Conclusion: MRI features of cavernous sinus invasion may be related to the expression of EMMPRIN and Galectin-3, MRI is very useful in diagnosing invasive extent of cavernous sinus in pituitary adenomas.
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Received: 27 August 2007
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Corresponding Authors:
HE Ning
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2008, Vol. 19 
