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| The correlation study on ultrasonographic features and molecular biology of breast cancer |
| WU Jun1, CAO Yong-zheng2, PENG Ge-hong2 |
| 1. Department of Ultrasound, the First Affiliated Hospital of Henan University, Kaifeng Henan 475001, China;2. Department of Ultrasound, Affiliated Hospital of Zunyi Medical College, Zunyi Guizhou 563003, China |
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Abstract Objective: To investigate the correlation between ultrasonographic features and molecular biology markers(ER, PR, CerbB-2) of breast cancer. Methods: The expressions of ER, PR and CerbB-2 in tumor tissue of 160 cases with breast cancer who were examined by ultrasonography in preoperation were detected by immunohistochemical techniques. Results: The positive expression rates of ER, PR were not significantly different between group of tumor size≥2.5cm and group of tumor size＜2.5cm by ultrasound examination(P＞0.05). The positive expression rate of CerbB-2 in group of tumor size≥2.5cm was higher than that in group of tumor size＜2.5cm, and was significantly different(P＜0.05). The positive expression rate of ER in group with spicula was higher than that without spicular edge, and was significantly different(P＜0.05). The positive expression rates of PR, CerbB-2 were not significantly different between spicular edge group and without spicular group(P＞0.05). The positve expression rates of ER, PR in patients with sufficient blood supply, axillary lymph nodes metastasis were lower than those with insufficient blood supply and no lymph node metastasis, but the positive of CerbB-2 was higher. Conclusion: The ultrasonographic features of breast cancer show correlation with the expressions of ER, PR, CerbB-2. Combination with these may viewed as a new valuable method to investigate malignant extent and prognostic evaluation in breast cancer.
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Received: 23 February 2009
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2009, Vol. 20 
