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| An experimental study of impact on biliary pressure after stent implantation in distal common bile duct in dogs |
| WEN Feng, LU Zai-ming, GUO Qi-yong, MAO Xiao-nan, LIANG Hong-yuan |
| Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China |
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Abstract Objective: To discuss the mechanism on the changes of the biliary pressure after metallic stent placement in distal common bile duct in dogs. Materials and Methods: Six healthy adult dogs were randomly selected, and then an animal model was accomplished to implant the metallic stent in distal common bile duct through percutaneous transhepatic biliary puncture. With biliary manometry, measured results of duodenal pressure(DP), sphincter of Oddi basal pressure(SOBP), sphincter of Oddi contractive amplitude(SOCA), sphincter of Oddi duration(SOD), common bile duct pressure(CBDP) were compared before and after stent implantation of distal common bile duct. Results: All of the six dogs were successfully performed with biliary puncture and pressure measurement. Five dogs were healthy and survived during the observation. DP was regarded as a zero, and then the relative results were obtained. Before stent placement, the results of SOBP, SOCA, SOD, CBDP were (13.69±4.29)mmHg, (42.65±8.50)mmHg, (6.69±1.46)s, (12.98±2.86)mmHg respectively. After 5 weeks of stent implantation, the results of which were as follows, (10.58±3.98)mmHg, (31.95±9.00)mmHg, (4.47±1.21)s, (7.43±2.20)mmHg respectively. Compared with those before stent implantation, SOCA was lower and SOD was shortened, and there were significant differences(P<0.05). CBDP was significantly lower than that before stent implantation, and had statistically significant difference(P<0.01). Conclusion: After 5 weeks of stent implantation in distal common bile duct in dogs, the changes of sphincter of Oddi motor function is manifested mainly in the weakened phasic contraction, but there is still the basic contraction. Although descending, the CBDP is still higher than normal DP, and maintains with the pressure gradient to the duodenum. So it is possible to prevent duodenobiliary reflux.
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Received: 30 September 2009
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2010, Vol. 21 
