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| Relationship between TNF-α, hsCRP and ultrasonic imaging of carotid atherosclerosis |
| ZHANG Tao, LEI Xin-jun |
| Department of Cardiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China |
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Abstract Objective: To study the relationship between serum level of TNF-α, hsCRP and ultrasonic imaging of carotid atherosclerosis. Materials and Methods: The patients with final diagnosis of carotid atherosclerosis as well as healthy individuals were selected and their serum level of TNF-α, hsCRP detected. Statistic methods were used in the interrelationship analysis of the serum level of TNF-α, hsCRP and degree of carotid atherosclerosis. Results: Totally 62 patients with carotid atherosclerosis and 25 healthy individuals were enrolled. The carotid atherosclerosis with ultrasonic image of intimae echo enhancement, rough surface, worse continuity and different shape as well as inequality of size of atherosclerotic plaque were analysed. The serum level of TNF-α in patients with carotid atherosclerosis was (51.4±6.6)μg/L, and was (8.8±1.2)μg/L in healthy individuals, which had significant difference(P<0.01). The serum level of hsCRP in patients with carotid atherosclerosis was (8.8±0.56)mmol/L, and (8.3±0.43)mmol/L in healthy individuals, which had significant difference(P<0.01). It had positive correlation with degree of carotid atherosclerosis(P<0.01). Conclusion: The serum level of TNF-α, hsCRP was significantly higher than those of the healthy individuals, and has positive relation with degree of carotid atherosclerosis.
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Received: 11 April 2011
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2011, Vol. 22 
