|
|
|
| The research of endothelial function and renal pathology in early-stage chronic kidney disease(CKD) patient |
| WANG Yuan, TONG Ming-hui, LU Hong-xia, CHEN Bin-juan, WANG Xiao-feng, LI Li |
| Department of Ultrasonography, the Second Hospital of Lanzhou University, Lanzhou 730030, China |
|
|
|
|
Abstract Objective: To study the endothelial dysfunction in early-stage chronic kidney disease(CKD) patients and to explore the relationship between Flow-Mediated Dilation(FMD) and renal pathology. Methods: Sixty subjects were divideded evenly into 3 groups: group A: normal control group; group B: renal patients without renal insufficiency; group C: renal hypertension patients without renal insufficiency. Each group underwent ultrasonographic examination of brachial artery diameter in the basic condition and the reactive hyperaemia. All renal patients had renal biopsy under ultrasound guidance. The degree of renal tissue damage made semiquantitative integral. We correlated endothelial function with age, pressure and renal pathology. Results: The FMD was impaired significantly in group C than that in group A and group B, but there was no difference in group A and group B; The FMD had a high correlation with systolic blood pressure, glomerular and interstitial damage index but no correlation with age and diastolic pressure. Conclusions: The endothelial function is impaired in renal hypertension patients without renal insufficiency; As the endothelial function becoming worse, renal pathological damage increased accordingly; Evaluation of the endothelial function by the high-resolution ultrasonography in early-stage CKD patients have clinical improtance．
|
|
Received: 11 May 2011
|
|
|
|
Corresponding Authors:
TONG Ming-hui
|
|
|
|
|
|
|
2011, Vol. 22 
