帕金森病的静息态脑功能局部一致性研究

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Abstract Objective: To investigate the changes of regional homogeneity in patients with Parkinson’s disease(PD), to study the central pathophysiological changes of PD. Methods: Totally 35 patients with PD and 31 normal persons as normal controls(NC) underwent resting-state BOLD-fMRI examination. The fMRI data were processed and analysed by DPARSF V2.0 soft and REST V1.8 soft. The Reho differences between PD group and NC group was statistically analyzed. Results: Compared with NC group, PD group had significantly increased Reho values in extensive brain regions including the right precuneus, left paracentral lobule, left interior frontal gyrus, left cerebellum posterior lobe; and the decreased regional activity in the right cerebellum posterior lobe, right lingual gyrus, right middle temporal gyrus, right inferior frontal gyrus, right middle occipital gyrus, right superior frontal gyrus, right precentral gyrus, left putamen, left middle occipital gyrus(P<0.05, K>29, AlphaSim corrected). Conclusions: The changes of Reho value in resting-state brain functional MRI of PD patients are extensive. The abnormal areas of neuronal activity included extensive cortex of striatal-thalamo-corti-cal loops, the default network key nodes, supplementary motor area and other parts.

Key words： Parkinson disease Magnetic resonance imaging

Received: 18 May 2015

PACS:	Ｒ742.5
	Ｒ445.2

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	Articles by authors
	FENG Jie-ying
	HUANG Biao
	ZHONG Xiao-ling
	YANG Wan-qun
	MAI Fa-ze

Cite this article:

FENG Jie-ying,HUANG Biao,ZHONG Xiao-ling, et al. A resting-state functional MRI study based on regional homogeneity in Parkinson’s disease[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2015, 26(12): 844-847.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2015/V26/I12/844

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