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| Clinical application value of gated SPECT myocardial perfusion imaging on cardiac resynchronization therapy in patients with chronic heart failure |
| LI Ting1, XU Wen-gui1, LI Jian-ming2, LU Ru-ming2, LIANG Yu2 |
| 1.Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China; 2.TEDA International Cardiovascular Hospital, Tianjin 300457, China |
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Abstract Objective: To investigate the clinical value of gated SPECT myocardial perfusion imaging on cardiac resynchronization therapy(CRT) and evaluate their prognosis in patients with chronic heart failure(CHF). Methods: Twenty one patients with CHF in 2012 January to 2014 June were assigned to CRT, and underwent gated SPECT myocardial perfusion imaging (GSMPI) before operation. Functional parameters including phase histogram bandwidth, phase standard deviation, left ventricular ejection function, end diastolic volume, summed rest scores and scar size were acquired by imaging. All patients underwent a second-time cardiac ultrasonography at the sixth month after operation. Effective therapy was considered when left ventricular end diastolic diameter decreased, LVEF increased, and no hospitalization records existed within half a year. Then, the patients were divided into effective and ineffective groups. The differences between the functional parameters of the two groups were compared, the predictive value for the efficacy of CRT was analyzed, and the latest systolic area in the left ventricule was recorded. Results: Fifteen cases(71.4%) were effective after CRT, and 6 cases(28.6%) were irresponsive. All parameters between the two groups showed significant differences(P<0.05), and PSD and PHB were the most significant(P<0.01). The latest systolic area of the left ventricle was located in the apex, the anterior wall and the septal wall in 10 patients’(47.63%), in the inferior wall in 6 patients(28.6%), and in the lateral wall in 5 patients(23.8%). Conclusion: GSMPI can provide “one-stop” multiple functional parameters, which can be used to guide CRT electrode implantation and predict curative effect. PSD and PSW might have a higher predictive value.
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Received: 09 October 2014
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2015, Vol. 26 
