健康成人脑白质扩散峰度成像与年龄相关性变化的初步研究

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Abstract Objective: To explore age-related changes of healthy adult white matter microstructure with diffusion kurtosis imaging(DKI). Methods: Sixty volunteers were divided into three groups according to age: 20 cases of young group(20～＜40 years), 20 cases of middle-aged group(40～＜60 years), 20 cases of elder group(≥60 years). Conventional MRI and DKI were performed. Fractional anisotropy(FA), mean kurtosis(MK), radial kurtosis(RK) and axial kurtosis(AK) were determined in the external capsule, the anterior limb of the internal capsule(ALIC), the posterior limb of the internal capsule(PLIC), the genu of the corpus callosum(CC), the splenium of the CC, the centrum semiovale, the frontal subcortical white matter(sWM). Parameter estimates were obtained and statistically analysed. Results: FA values in the ALIC, genu and splenium of the CC, centrum semiovale and frontal sWM were significant negative correlation with age(P<0.05). FA values in the ALIC and frontal sWM were shown as follows: young group>elder group(P<0.017). FA values in the genu and splenium of the CC and centrum semiovale were shown as follows: young group>middle-aged group, young group>elder group. MK values in the all selected white matter areas were significant negative correlation with age. MK values in the external capsule, PLIC, genu and splenium of the CC, centrum semiovale and frontal sWM were shown as follows: young group>middle-aged group>elder group. MK values in the ALIC were shown as follows: young group>middle-aged group, young group>elder group. RK values in the all selected white matter areas were significant negative correlation with age. RK values in the ALIC, genu and splenium of the CC, centrum semiovale and frontal sWM were shown as follows: young group>middle-aged group>elder group. RK values in the external capsule and PLIC were shown as follows: young group>middle-aged group, young group>elder group. AK values in the all selected white matter areas did not show age dependence. The average FA, MK and RK values from all selected white matter areas were significant negative correlation with age(r values were -0.775, -0.933 and -0.946, respectively). The average AK values did not show age dependence. Conclusion: DKI can offer a more comprehensive and sensitive detection of age-related changes of healthy adult white matter microstructure compared with DTI.

Key words： Brain Age factors Diffusion magnetic resonance imaging

Received: 18 January 2016

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	Ｒ445.2

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	XIE Ming-fei
	GAO Si-jia
	HU Wen
	SU Yu
	LI Dan

Cite this article:

XIE Ming-fei,GAO Si-jia,HU Wen, et al. A preliminary study of age-related changes of healthy adult white matter with diffusion kurtosis imaging[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(10): 685-689.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I10/685

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