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| Related factors for coronary artery damage of level Ⅱ, Ⅲ and Ⅳ in Kawasaki disease evaluated by echocardiography |
| WANG Jing, ZHANG Chun-xia, XUE Mei, ZHANG Dan, HU Yan-hua, ZHANG Xiao-shan |
| The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China |
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Abstract Objective: To analyze the related factors for coronary artery lesions(CAL) of level Ⅱ, Ⅲ and Ⅳ in Kawasaki disease(KD) diagnosed by echocardiography. Methods: We collected 416 children with KD as the research object in the past five years. We found 179 cases of level Ⅱ, Ⅲ and Ⅳ damage by echocardiography, defined as the case group, and 237 cases without damage, defined as the control group. We collected 44 clinical items such as age, gender and platelet count, which may be the related factors for artery damage of level Ⅱ, Ⅲ and Ⅳ in two groups. Data were analyzed by single factor analysis and multivariable logistic regression. Results: Increase of thermal process by 1 day, increase of platelet by 1×109 L-1, increase of blood sedimentation by 1 mm/h, increase of c-reactive protein by 1 μg/L and increase of N terminal brain natriuretic peptide precursor by 1 ng/L increased the risk of level Ⅱ, Ⅲ and Ⅳ damage by 1.254, 2.813, 1.073, 3.845 and 1.083 times, respectively, compared with the control(OR>1, the 95% confidence interval did not contain 1, P<0.05), and accelerated the course of the disease. The risk of level Ⅱ, Ⅲ and Ⅳ damage(OR>1, the 95% confidence interval did not contain 1, P<0.05) was 12.276 times higher in male than female, and also promoted the disease. IVIG and its initial time of 5~<10 days decreased the risk of level Ⅱ, Ⅲ and Ⅳ damage by 0.412 and 0.115 times, respectively, compared with those who were not given IVIG or with initial time <5 days or ≥10 days, (OR<1, the 95% confidence interval did not contain 1, P<0.05). Conclusion: Increasing of thermal process, platelet, blood sedimentation, C-reactive protein, N terminal brain natriuretic peptide precursor and male are risk factors for level Ⅱ, Ⅲ and Ⅳ damage. And IVIG with initial time of 5~9 days are its protective factors.
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Received: 12 April 2016
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