3.0T磁共振SWI在2型糖尿病脑微出血与认知功能影响的临床研究

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Abstract Objective: To study type 2 diabetic encephalopathy microvascular disease by SWI with cerebral microbleeds(CMBs) as biological markers, and explore the impact of cognitive dysfunction in diabetes. Methods: We recruit patients with type 2 diabetes with cognitive dysfunction by montreal cognitive scale(MoCA) in 30 cases, and patients with type 2 diabetes, having non-recognition dysfunction in 30 cases, which matched by age, sex and education level. Each subject’s MoCA total score and the specific score were recorded, then underwent conventional MRI and SWI scan. The number and location of CMBs on SWI images of two groups were examined. Results: In all 57 cases, 26 cases had CMBs, CMBs prevalence was 45.6%. There were 155 CMBs, the number and distribution of CMBs were common in subcortical/cortical areas, there were 107 CMBs at subcortical/cortical areas, lower hemisphere deep CMBs were 41, brainstem and curtain CMBs were 7, accounting for the total respectively 69.0%, 26.5%, 4.5%. The two groups had significant difference in the number and case of CMBs(P<0.05). The two groups had significant difference in the case of CMBs in difference area of brain(P<0.05). According to Spearman correlation analysis results, the CMBs number was negatively correlated with total MoCA scores, visuospatial skills and execution function scores, attention scores, language scores, abstracting scores and memory scores(P＜0.05). Conclusion: CMBs is an independent factors affecting cognitive function in diabetic patients, and there is a trend that with an increase of the number of CMBs, it leads the more severe cognitive impairment.

Key words： Diabetes mellitus, type 2 Cerebral hemorrhage Cognition disorders Magnetic resonance imaging

Received: 20 June 2015

PACS:	Ｒ743.34
	R587.1
	Ｒ445.2

Corresponding Authors: LIU Jin-cai

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LIU Wen-wen,LIU Jin-cai. 3.0T MRI SWI clinical study of cerebral microbleeds in type 2 diabetes and association with cognitive function[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(3): 161-166.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I3/161

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