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| Analysis of cerebral gray matter structural changes in autistic children by IBASPM |
| Tianjin Children’s Hospital, Tianjin 300074, China |
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Abstract Objective: To analyse the volume changes of gray matter structures in different brain regions of autistic children by using IBASPM software based on SPM. Methods: Twenty-three autistic children diagnosed by clinical features and 28 healthy children were selected in this study, whose age and sex were matched. High resolution T1 weighted images of each child’s whole brain were acquired by using 3D FSPGR sequence on GE HDx 1.5T MRI. The raw data was dealed with IBASPM software based on SPM5, to obtain the volume value of every brain region. Two independent sample t-test was used to compare the groups. Results: The data of 16 autistic children and 18 normal controls matched the experimental requirements. The autism group included 11 males and 5 females, whose mean age was 2.81±0.91 years old. The normal control group included 11 males and 7 females, whose mean age was 2.61±0.50 years old. Compared with the normal control group, the volume values of the left mid cingulum, left supramarginal gyrus, bilateral amygdaloid body and bilateral caudate nucleus were enlarged in the autism group; the volume value of vermis Ⅷ area was decreased. Conclusion: Some gray matter structures of autistic children were abnormally changed, which were related to emotion, language and behavior control, and then provided an objective basis for the interpretation and diagnosis of clinical symptoms of autism. The IBASPM software can be used to automatically measure the volumes of different brain regions, and to morphologically analyse the gray matter structures of autistic children.
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Received: 21 October 2015
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2016, Vol. 27 
