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| Three-dimensional speckle tracking imaging in evaluation on global left ventricular strain in children with initial onset of nephrotic syndrome |
| Department of Sonography, Shengjing Hospital of China Medical University, Shenyang 110004, China |
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Abstract Objective: To evaluate the characters of global left ventricular(LV) strain in children with initial onset of nephrotic syndrome(INS) by three-dimensional speckle tracking imaging(3D-STI) technique. And to analysis the differences of the above data between the children with various amount of urine protein in 24 h. Methods: Forty-two INS children were randomly enrolled as INS group, and 30 healthy children were employed as normal controls. Three-dimensional left ventricular ejection fraction(3D-LVEF), global left ventricular longitudinal strain(LVGLS), left ventricular circumferential strain(LVGCS), left ventricular area strain(LVGAS) and left ventricular radial strain(LVGRS) were measured with 3D-STI. All of the data were analyzed by normality test to find out the proper statistical approaches. Then we choose 20 groups randomly to do the repeatability test. Meanwhile, we draw the scatter diagram. At last, we divided the INS group into 3 groups according to their various amount of urine protein in 24 h. Results: ①LVGLS and LVGAS were significant lower in INS group than in normal group(all P<0.05) while LVGCS and LVGRS have no significant differences. ②After the Bland-Altman’s repeatability test, it turned out that the 20 groups which were chosen randomly are in good correspondence with each other not only between-group but also in-group. Compared with between-group, the mean difference value of LVGAS, LVGCS, LVGLS and LVGLS are -0.2, -0.13, 0.1 and 0.2 respectively as well as the confidence interval of them are -2.8%~2.3%, -1.65%~1.29%, -2.1%~2.3% and -3.9%~4.3% respectively. When compared with in-group, the mean difference value of LVGAS, LVGCS, LVGLS and LVGLS are 0.0, -0.36, -0.4 and 0.1 respectively as well as the confidence interval of them are -2.9%~2.9%, -2.18%~1.45%, -3.2%~2.4% and -4.4%~4.6% respectively. ③Compared the data among the 3 INS subgroups, it can be inferred that only LVGAS and LVGLS make the significant differences. With the increasing amount of the urine protein, the data above can go down. Conclusion: The global left ventricular strain in children with INS has significant differences in our study. The new technology used in our study can be well repeated in the same way. The global left ventricular strain may be related to the severity level of the disease.
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Received: 21 October 2015
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