Alzheimer病患者脑内扩大的血管周围间隙的临床意义

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Abstract Objective: To explore the imaging features of enlarged perivascular spaces(EPVS) in basal ganglia and centrum semiovale in mild cognitive impairment(MCI) and Alzheimer disease(AD) patients, and to analyze the relationship between EPVS and cognitive impairment． Methods: In this study, 30 patients with AD(AD group, mini-mental state examination(MMSE)<24), 20 patients with MCI(MCI group, 24≤MMSE<27) and 30 normal controls(NC group, MMSE≥27) were reviewed retrospectively. EPVS in both the basal ganglia and centrum semiovale were counted in axial images according to the following standard: 1 score for EPVS less than 10, 2 scores for EPVS between 11 to 20, 3 scores for EPVS between 21 to 40 and 4 scores for EPVS more than 40. Kruskal-Wallis test and Kolmogorov-Smirnov Z test were used to analyze the inter-group difference. Relationship between the scores of EPVS and MMSE was explored using Spearman’s correlation analyses. Results: Significantly statistical differences of EVPS score in both the basal ganglia and centrum semiovale were found among the three groups(H values respectively=26.45, 41.4, all P<0.01). In the basal ganglia, EPVS score in AD group(1.80±0.71) was higher than that in NC group(1.06±0.25)(P＜0.01), and there was no difference of EPVS scores between MCI and NC group(P>0.05). In the centrum semiovale, EPVS scores in AD group(2.93±0.83) was obviously higher than that in MCI group(2.40±0.68) and NC group(1.40±0.50, P＜0.01). There were correlations between the scores of EPVS and MMSE in both the basal ganglia and centrum semiovale(r values respectively=-0.708, -0.594, all P<0.01). Besides, in the NC group, there was correlation between the score of EPVS and MMSE in the basal ganglia(r=0.418, P＜0.05）. Conclusion: In patients with AD, EPVS is a common phenomenon in both the basal ganglia and centrum semiovale, and it can help to evaluate the changes of cognitive abilities.

Key words： Alzheimer disease Magnetic resonance imaging

Received: 22 September 2016

PACS:	Ｒ749.16
	Ｒ445.2

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	Articles by authors
	SHANG Jin
	LIU Yang-ying-qiu
	WANG Wei-wei
	SONG Qing-wei
	MIAO Yan-wei

Cite this article:

SHANG Jin,LIU Yang-ying-qiu,WANG Wei-wei, et al. Clinical significance of enlarged perivascular spaces in Alzheimer disease patients[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(6): 387-390.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I6/387

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