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| The values of MR perfusion weighted imaging in evaluating rabbit liver fibrosis |
| HAN Bing-yan, WANG Hao, WANG Yun-ling, WANG Lu-wei, WANG Hong, JIA Wen-xiao |
| Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China |
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Abstract Objective: To evaluate the diagnostic value of MR perfusion weighted imaging(PWI) for liver fibrosis in rabbit model. Methods: MR PWI was performed in the experimental group(n=40) and the control group(n=10). Time to peak(TP), wash-in rate and wash-out rate were compared with histological results by using one-way ANOVA Least significant difference(LSD) was used between two groups. The diagnostic efficiency of staging liver fibrosis was done by using ROC curve analysis. Results: With the deterioration of liver fibrosis, time to peak(TP) of liver parenchyma increased gradually, however, the wash-in rate and wash-out rate decreased. For TP, there was signifcant difference among stage S0~S2, S3 and S4(P<0.05). For wash-in rate, there was signifcant difference among stage S0 and S2, S3 and S4(P<0.05). Concerning wash-out rate, S3 and S4 stage can be distinguished from S0~S2 stage(P<0.05). After merging fibrosis stages, there was signifcant difference among stage S0 and ≥S1, ≤S1 and ≥S2, ≤S2 and ≥S3, ≤S3 and S4(P<0.05). Conclusion: Combining the TP and the signal rise maximum slope rate can reflect perfusion changes of liver fibrosis in different periods with highest diagnostic efficiency in stages over S2.
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Received: 10 October 2016
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