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| The study of pseudo-continuous arterial spin labeling technique on cerebral blood flow in children with cerebral palsy |
| WANG Lu-wei, XIE Chao, WANG Yun-ling |
| Department of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Urumchi 830028, China |
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Abstract Objective: To investigate the effect of pseudo-continuous arterial spin labeling(pCASL) on cerebral blood flow(CBF) in cerebral palsy(CP) children with sympathetic plexus stripping of common carotid artery. Methods: In this study, 50 CP children with sympathetic plexus stripping of common carotid artery and 20 healthy children were selected from October 2015 to March 2017 in our hospital. The pCASL perfusion MRI examination was performed on normal control group and CP children before and after treatment 7 d and 6 months. And Philips pride software was used to analyze the CBF values in bilateral basal ganglia, parietal lobe gray matter, corona radiata white matter. Besides, the improvement of clinical symptoms of CP children after operation were observed. Results: Before operation, CBF value of CP children was significantly lower than that of the control children by pCASL, there was a significant difference between the two groups, P<0.05. But the values of CBF of CP children after surgery for 7 d and 6 months were still lower than those of the control children, with statistical difference, P<0.05. The CBF value of CP children after the operation for 6 months was significantly higher than that before operation and after operation for 7 d, with statistical difference, P<0.05. In addition, the clinical symptoms of CP children such as speech disorders, muscle tone abnormalities, ataxia, strabismus and salivation were improved obviously. Conclusion: The pCASL can be used in the evaluation of CBF in CP children, and the dynamic observation of the CP children with sympathetic plexus stripping of common carotid artery, which would be recommended for the clinical use as an effective choice.
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Received: 05 December 2017
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