扩张型心肌病左心结构功能心脏磁共振评价与NT-proBNP相关性研究

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Abstract Objective: Dilated cardiomyopathy(DCM) is characterized with left ventricular dilatation and dysfunction, which has a high morbidity and mortality. Our study is to investigate relationship between the left ventricular function by cardiac magenetic imaging(CMR) and plasma NT-proBNP levels in DCM. Methods: Twenty-two cases of DCM were enrolled. All patients received CMR examination and NT-proBNP level test. The imaging data of CMR were transferred to cardiac explorer workstation and the parameters of left ventricular structure and function were calculated. The parameters included LVEDV, LVESV, LVEF, SV, CO, CI, LVMM, FS, LVEDD, and SI. The correlation between all the parameters and plasma NT-proBNP levels was analyzed. Result: The plasma NT-proBNP levels in patients with DCM had a linear correlation with LVEDV, LVESV, LVEF, LVMM, FS, LVEDD and SI. The plasma NT-proBNP levels showed a positive correlation with LVEDV(r＝0.596, P＝0.003), LVESV(r＝0.742, P＝0.000), LVMM(r＝0.763, P＝0.000) and LVEDD(r＝0.629, P＝0.002) and negative correlation with LVEF(r＝-0.829, P＝0.000), FS(r＝-0.623, P＝0.002) and SI(r＝-0.539, P＝0.010). The coefficient of correlation between plasma NT-proBNP levels and LVEF was the highest. Conclusion: CMR can provide more valuable information for left ventricular remodeling and function in DCM patients. The more dilatation of the left ventricular chamber, the worse the cardiac function, the heavier the myocardial burden, and the higher the plasma NT-proBNP levels are. It demonstrates that the plasma NT-proBNP levels can reflect the severity of cardiac structure and function, and further reflect the severity of ventricular remodeling.

Key words： Cardiomyopathy, dilated Ventricular function, left Magnetic resonance imaging

Received: 25 August 2017

PACS:	Ｒ542.2
	Ｒ331.3
	Ｒ445.2

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	ZHANG Ying-xue1
	ZHAO Xin-xiang2

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ZHANG Ying-xue1,ZHAO Xin-xiang2. Evaluation of left ventricular function by cardiac magnetic imaging in dilated cardiomyopathy and #br# the relationship with plasma NT-proBNP levels[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(6): 404-408.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2018/V29/I6/404

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