|
|
|
| Imaging of SAPHO involvement in spine |
| ZHANG Li-hua, YUAN Hui-shu, DENG Xiao-li, GAO Shuang, SONG Le |
| Peking University Third Hospital, Beijing 100190, China |
|
|
|
|
Abstract Objective: To explore imaging features of synovitis, acne, pustulosis, hyperostosis, and osteitis(SAPHO) syndrome with vertebral involvement. Methods: Clinical and imaging data of 26 cases(16 male and 10 female; age between 26 to 73 years old, mean age (48.5±12.5) years) clinically confirmed as SAPHO syndrome were analyzed retrospectively. Imaging features of CT and MRI were described. Results: The number of thoracic, lumbar and cervical spine involved was 13, 10 and 6 respectively. Five cases had cervical-thoracic or thoracic-lumbar involvement. The number of spine involvement was between 2 to 10 and mean value was 3.4±0.8. Contiguous involvement of 2 vertebral bodies or more was found in 9 cases. Edema of vertebra body was found in 11 cases and bone erosion and bone sclerosis were present in 8 and 9 cases, respectively. Endplate irregularity was found in 10 cases. Six cases showed T2 hyperintensity in intervertebral discs and three cases showed narrowed intervertebral space. Thickened paraspinal soft-tissue was present in 4 cases and calcification of ligament was present in 2 cases. Other involvement locations included sternoclavicular, sternocostal joint, rib and sacroiliac joint and these are commonly seen SAPHO. Conclusion: SAPHO with spine involvement is not rare and thoracic is the most commonly involved segment, with lumbar and cervical segment following. Contiguous involvement of two or more segments is commonly seen and other commonly involvement location is sternoclavicular joint. Imaging appearance is diverse and several methods are needed to detect all of these lesions.
|
|
Received: 28 July 2017
|
|
|
|
|
|
[1]Chamot AM, Benhamou CL, Kahn MF, et al. Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases[J]. Rev Rhum Mal Osteoartic, 1987, 54(3): 187-196.
[2]Benhamou CL, Chamot AM, Kahn MF. Synovitis-acne-pustulosis hyperostosis-osteomyelitis syndrome (SAPHO): a new syndrome among the spondyloarthropathies?[J]. Clin Exp Rheumatol, 1988, 6(2): 109-112.
[3]Stern SM, Ferguson PJ. Autoinflammatory bone diseases[J]. Rheum Dis Clin North Am, 2013, 39(4): 735-749.
[4]Takigawa T, Tanaka M, Nakanishi K, et al. SAPHO syndrome associated spondylitis[J]. Eur Spine J, 2008, 17(10): 1391-1397.
[5]Aljuhani F, Tournadre A, Tatar Z, et al. The SAPHO syndrome: a single-center study of 41 adult patients[J]. J Rheumatol, 2015, 42(2): 329-334.
[6]McGauvran AM, Kotsenas AL, Diehn FE, et al. SAPHO Syndrome: Imaging Findings of Vertebral Involvement[J]. Am J Neuroradiol, 2016, 37(8): 1567-1572.
[7]Xu W, Li C, Zhao X, et al. Whole-spine Computed Tomography Findings in SAPHO Syndrome[J]. J Rheumatol, 2017, 44(5): 648-654.
[8]Laredo JD, Vuillemin-Bodaghi V, Boutry N, et al. SAPHO syndrome: MR appearance of vertebral involvement[J]. Radiology, 2007, 242(3): 825-831.
[9]Depasquale R, Kumar N, Lalam RK, et al. SAPHO: What radiologists should know[J]. Clin Radiol, 2012, 67(3): 195-206.
[10]Toussirot E, Dupond JL, Wendling D. Spondylodiscitis in SAPHO syndrome: a series of eight cases[J]. Ann Rheum Dis, 1997, 56(1): 52-55.
[11]Akisue T, Yamamoto T, Marui T, et al. Lumbar spondylodiscitis in SAPHO syndrome: multimodality imaging findings[J]. J Rheumatol, 2002, 29(5): 1100-1101.
[12]Mulleman D, Mammou S, Griffoul I, et al. Ossification of the posterior longitudinal ligament of the cervical spine and SAPHO syndrome[J]. J Rheumatol, 2005, 32(7): 1361-1364.
[13]Paparo F, Revelli M, Semprini A, et al. Seronegative spondyloarthropathies: what radiologists should know[J]. Radiol Med, 2014, 119(3): 156-163.
[14]张强，次旦旺久，孙洪赞，等. CT与核素骨显像诊断SAPHO综合征的对比分析[J]. 中国临床医学影像杂志，2016，27（8）：589-593.
[15]Leone A, Cassar-Pullicino VN, Casale R, et al. The SAPHO syndrome revisited with an emphasis on spinal manifestations[J]. Skeletal Radiol, 2015, 44(1): 9-24. |
|
|
|
