儿童抗N-甲基-D-天冬氨酸受体脑炎的影像表现与临床特征

doi:10.12117/jccmi.2019.11.003

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Abstract Objective: To discuss the imaging and clinical features of anti-N-methyl-D-aspartate(NMDA) receptor encephalitis patients in children. Methods: Thirty-four anti-NMDA receptor encephalitis patients in children were included. We analyzed the brain MRI findings and the clinical characteristics. The modified Rankin scale(mRS) was applied on admission and after 6 months for each patient. Result: The brain MRI was abnormal in 17/34 patients. The initial MRI was abnormal on T2 or fluid-attenuated inversion recovery(FLAIR) as hyper-intensity signals. They were seen in the temporal lobe, insular lobe, frontal and parietal and occipital lobe. Some of them were also found in basal ganglia, thalamus, corpus callosum, brainstemand cerebellum. Six has leptomeningeal enhancement and/or abnormal enhancement of parenchyma. The first symptom is seizure, followed by mental and behavioral disorders(35%), fever(32%), motor disorders(17.6%) and loss of consciousness(17.6%). There were no statistically significant differences between the MRI findings and clinical presentations(seizure, mental and behavioral disorders, fever, motor disorders, oss of consciousness, erpes simplex virus infection)(P>0.05). There was no statistically significant difference in MRI findings(normal or abnormal) between 34 patients with different age(P>0.05). There was no statistically significant difference in MRI findings(normal or abnormal) between the mean mRS score at 0-month follow-up(P>0.05). The mean mRS score at the 6-month follow-up was significantly lower in patients with normal MRI than in patients with abnormal MRI(P<0.05). Conclusion: The patients with normal MRI had improved outcomes, and the patients with abnormal MRI had poor outcoms.

Key words： Encephalitis Child Receptors, N-methyl-D-aspartate Magnetic resonance imaging

Received: 01 February 2019

PACS:	Ｒ512.3
	Ｒ445.2

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	Articles by authors
	YIN Yan
	JIN Ke
	ZHUANG Xia-mei
	WANG Hai

Cite this article:

YIN Yan,JIN Ke,ZHUANG Xia-mei, et al. Imaging and clinical features of anti-N-methyl-D-aspartate receptor encephalitis in children[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(11): 769-772.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2019.11.003 OR http://www.jccmi.com.cn/EN/Y2019/V30/I11/769

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