基于呼、吸双相CT在慢性阻塞性肺疾病患者气道病变的定量分析

doi:DOI:10.12117/jccmi.2019.12.005

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the differences in airway quantitative parameters of respiratory biphasic CT and the correlation between various parameters and pulmonary function in patients with chronic obstructive pulmonary disease(COPD). Methods: We retrospectively analyzed 47 patients with pulmonary function diagnosed as COPD who underwent expiratory and inspiratory biphasic CT scan. Then we imported the data into the “Dexin-FACT” automatic analysis software, quantitatively analyzed the airway parameters in right lower lobe, including the mean wall thickness(MWT) of the bronchus, the average diameter(MLD) of the bronchial lumen, the mean wall area(MWA) of the bronchial wall area and the percentage of the wall area(mean wall ratio, WA%). Paired sample t test was used to determine the differences of CT parameters; correlation between MWT, MLD, MWA, WA% and lung function was performed by using Preason correlation analysis. Results: There were significant differences in bronchial MWT, MLD, MWA and WA% between the two groups of respiratory and inspiratory phases(P<0.05). MWT of inspiratory was bigger than expiratory; MLD and MWA of expiratory are bigger than inspiratory phase; there were statistically significant differences in WA% between biphasic CT in 0～3th generations of bronchi(P<0.05). WA% of inspiratory was bigger than expiratory, there were no statistically significant differences among WA% of 4th～9th generations bronchi(P>0.05). The MWT, MLD, MWA, WA% and FEV1%, FEV1/FVC, MEF25% of 9th generation bronchi in biphasic CT have correlations in the right lower lobe(P<0.05); In 8th generation of bronchi, MWT and FEV1% at expiratory, MWT and MEF25% in biphasic CT, MLD and MEF25% in biphasic CT, WA and FEV1%, MEF25% in biphasic CT, WA and FEV1/FVC at expiratory, WA% and FEV1%, FEV1/FVC, MEF25% in biphasic CT were have some correlations(P<0.05); There were some correlations between WA% and FEV1%, FEV1/FVC, MEF25% of 7th generation of bronchi in biphasic CT(P<0.05). The quantitative parameters of each bronchus have negative correlations with PFT, and the correlations increased with the increase of generations. The correlations between parameters at expiratory and PFT was higher than that of inspiratory. The WA% of bronchi of 9th generation in expiratory have the highest correlation with MEF25%(|r|=0.697, P<0.05). There were no correlations between other bronchi and PFT(P>0.05). Conclusion: Biphasic CT scanning is important for the diagnosis of small airway diseases in patients with COPD, so as to better guide clinical individualized treatment.

Key words： Pulmonary disease, chronic obstructive Tomography, spiral computed

Received: 09 January 2019

PACS:	Ｒ563
	Ｒ814.42

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHAO Fan-hui
	WANG Lei
	ZHU Yan-jin
	LI Jian-long
	GUO You-min
	HUANG Xiao-qi

Cite this article:

ZHAO Fan-hui,WANG Lei,ZHU Yan-jin, et al. Quantitative analysis of airway disease in patients with chronic obstructive pulmonary disease based on biphasic CT[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(12): 855-858.

URL:

http://www.jccmi.com.cn/EN/DOI:10.12117/jccmi.2019.12.005 OR http://www.jccmi.com.cn/EN/Y2019/V30/I12/855

[1]Nirupama P, Drummond MB, Robert AW, et al. Comorbidities and Chronic Obstructive Pulmonary Disease: Prevalence, Influence on Outcomes, and Management[J]. Semin Respir Crit Care Med, 2015, 36(4): 575-591. [2]Sakuraiiesato Y, Kawata N, Tada Y, et al. The Relationship of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease Classified According to the Global Initiative for Chronic Obstructive Lung Disease(GOLD) Combined Chronic Obstructive Pulmonary Disease(COPD) Assessment System[J]. Intern Med, 2017, 56(14): 1781-1790. [3]Yamashiro T, Matsuoka S, Bartholmai BJ, et al. Collapsibility of lung volume by paired inspiratory and expiratory CT scans: correlations with lung function and mean lung density[J]. Acad Radiol, 2010, 17(4): 489-495. [4]Chung MH, Gil BM, Kwon SS, et al. Computed tomographic thoracic morphologic indices in normal subjects and patients with chronic obstructive pulmonary disease: Comparison with spiral CT densitometry and pulmonary function tests[J]. Eur J Radiol, 2018, 100(8): 147-153. [5]陈亚红. 2018年GOLD慢性阻塞性肺疾病诊断、治疗及预防全球策略解读[J]. 中国医学前沿杂志：电子版，2017，9（12）：15-22. [6]Eapen MS, Myers S, Walters EH, et al. Airway inflammation in chronic obstructive pulmonary disease(COPD): a true paradox[J]. Expert Rev Respir Med, 2017, 11(10): 827-839. [7]纪蒙蒙，耿鹤群，杨飞，等. 慢性阻塞性肺疾病急性加重期小气道CT定量研究[J]. 中国医学影像学杂志，2015，23（3）：195-199. [8]暴锐，鄂林宁，吴山，等. MSCT双相扫描定量分析COPD患者小气道重塑与肺功能相关性[J]. 山西医科大学学报，2017，48（4）：348-351. [9]Fernandes L, Fernandes Y, Mesquita AM. Quantitative computed tomography imaging in chronic obstructive pulmonary disease[J]. Lung India, 2016, 33(6): 646-652. [10]管宇，范丽，夏艺，等. 慢性阻塞性肺疾病患者小气道重塑及肺叶水平肺气肿的CT定量分析及其与肺功能的相关性研究[J]. 中国医学影像技术，2015，31（2）：181-185. [11]叶文婧，宋琳，郭雪君. 多层螺旋CT在评估慢性阻塞性肺疾病及支气管哮喘患者小气道功能方面作用的研究进展[J]. 国际呼吸杂志，2015，35（5）：380-383． [12]房宾，武志峰. 慢性阻塞性肺疾病患者支气管壁厚度与肺功能的相关性[J]. 中国医学影像技术，2011，27（4）：751-755． [13]Diaz AA, Estépar RS, Washko GR. Computed Tomographic Airway Morphology in Chronic Obstructive Pulmonary Disease. Remodeling or Innate Anatomy?[J]. Ann Am Thorac Soc, 2016, 13(1): 4-9.