组织弹性成像预测乳腺癌新辅助化疗效果的价值

doi:10.12117/jccmi.2019.06.004

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Abstract Objective: To explore the value of real-time tissue elastography(RTE) in predicting the efficacy of neoadjuvant chemotherapy(NAC) in breast cancer. Methods: A total of 60 patients with breast cancer who received NAC in our hospital were recruited. According to the pathological results, 47 patients were included in the significant response group and 13 patients were in the non-significant response group. The maximum diameter and strain ratio(B/A ratio) of lesions before and after NAC for 1, 2, 4 and 6 weeks was recorded and compared. The ROC curve of the lesion diameter and strain rate ratio(B/A value) was used to predict the value of NAC efficacy. Results: The lesions in the two groups showed a honeycomb-like reduction after NAC. The blue color in the elastic image gradually decreased, and the green color gradually increased. Repeated measurement analysis of variance found that the maximum diameter and B/A value showed a downward trend within 6 weeks of NAC treatment. The maximum diameter and B/A value in the significant response group were significantly lower than the non-significant response group before and after the NAC. There was an interaction in the maximum diameter and B/A value between the significant response group and the non-significant response group. The above differences were statistically significant(all P<0.05). The AUC of ΔB/A value at 2 weeks of NAC was maximal(0.944), and the best diagnostic point was 5.64. The sensitivity was 92.31% and the specificity was 87.23%. Conclusion: ΔB/A value at 2 weeks of NAC has certain value in predicting the therapeutic effect of NAC in breast cancer, and it is expected to be applied in clinical diagnosis.

Key words： Breast neoplasms Antineoplastic combined chemotherapy protocols Ultrasonography, Doppler, color

Received: 06 July 2018

PACS:	Ｒ737.9
	Ｒ730.5
	Ｒ445.1

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	Articles by authors
	HU Li-hua
	MA Yuan
	LIU Xiao-zhi
	MA Ying

Cite this article:

HU Li-hua,MA Yuan,LIU Xiao-zhi, et al. Value of tissue elastography in the prediction of neoadjuvant chemotherapy in breast cancer[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(6): 394-397.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2019.06.004 OR http://www.jccmi.com.cn/EN/Y2019/V30/I6/394

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