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| The application value of MR DWI quantitative parameters in neonatal hypoglycemic brain injury |
| XIE Hui, LAN Wei-shun, YANG Wen-zhong, YU Xu-dong, YUAN Xian-hong, LIU Ping |
| Department of Radiology, Hubei Maternal and Children’s Hospital, Wuhan 430070, China |
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Abstract Objective: To explore the diagnostic value of conventional MRI sequence and ADC value of DWI in neonatal hypoglycemic brain injury. Methods: A total of 48 cases of neonatal hypoglycemic brain injury were included with complete clinical, imaging and laboratory data from June 2016 to January 2019 in our hospital. The MRI findings were analyzed, and we divided the 48 cases into 3 groups according to the blood glucose level(group a: ≤1.0 mmol/L, group b: ＞1.0~1.7 mmol/L, group c: ＞1.7~2.2 mmol/L). We use SPSS 23.0 software to analyze the difference of ADC values among different groups and the correlation with blood glucose. Results: ①There were 17 patients in group a, 17 patients in group b, and 14 patients in group c. Among them, lesions of 28(58%) were more obviously showed in DWI than in conventional sequences(T1WI, T2WI). ②The ADC values were different among different groups(a, b, c). As the severity of hypoglycemia increased, the ADC value decreased, and the difference was statistically significant(P<0.01). ③The ADC value was strongly correlated with the severity of hypoglycemia, and the correlation coefficient r was 0.761. Conclusion: DWI is more sensitive in showing the location, extent and severity to hypoglycemic brain injury than MRI routine sequences. ADC value plays an important role in evaluating the severity of neonatal hypoglycemic brain injury.
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Received: 17 June 2019
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