肝细胞性肝癌超声造影定量分析与P53表达相关性研究

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Abstract Objective: To investigate the expression of mutant P53 protein and their correlation with contrast-enhanced ultrasound quantitative parameters in hepatocellular carcinoma(HCC). Methods: Fifty-seven cases of HCC were enrolled. A retrospective analysis of the contrast-enhanced ultrasound quantitative parameters was performed, and then their correlation with P53 protein by immunohistochemistry staining method was done. Results:①P53 positive expression rate was 54.3%(31/57). ②In P53 positive and negative groups, the peak strength, the mean transit time and time to peak showed no significant difference(P>0.05). There was significant difference in the rising slope and washout time(P<0.05). ③There was no correlation between the expression of P53 and maximum intensity, mean transit time or time to peak(P>0.05). The positive expression of P53 was positively correlated with the rising slope with r=0.377(P<0.05), and negatively correlated with washout time with r=-0.410(P<0.05). Conclusion: For HCC contrast-enhanced ultrasound parameters, there is a certain correlation between rising slope, washout time and mutant P53 protein expression. The time-intensity curve might noninvasively assess the expression of P53.

Key words： Liver neoplasms Carcinoma, hepatocellular Genes, p53 Ultrasonography, Doppler, color

Received: 26 April 2015

PACS:	Ｒ735.7
	Ｒ445.1

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	Articles by authors
	MA Zhen1
	YANG Hong2
	HE Yun2
	LU Jing-ning2
	PENG Jin-bo2
	WU Yu-quan2

Cite this article:

MA Zhen1,YANG Hong2,HE Yun2, et al. A correlation study of CEUS quantitative analysis and the expression of P53 in hepatocellular carcinoma[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(1): 25-28.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I1/25

[1]Jemal A, Center MM, Ward E, et al. Cancer occurrence[J]. Cancer Epidemiol, 2009, 471(1): 3-29.
[2]Shariff MI, Jane C, Gomaa AI, et al. Hepatocellular carcinoma:current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics[J]. Expert Rev Gastroenterol Hepatol, 2014, 4(4): 19-37.
[3]Gartd AL, Radhakfishnan SK. Lost in transcription: p2l repression mechanisms, and consequences[J]. Cancer Res, 2005, 65(10): 3980-3985.
[4]Toegel S, Hoffmann O, Wadsak W. Uptake of bone-seekers issolely associated with mineralization A study with 99mTc-MDP, 153Sm EDTMP and 18F-fluoride on osteoblasts[J]. Eur J Nucl Med Mol Imaging, 2006, 33(4): 491-494.
[5]Patard JJ, Rioux-Leclercq N, Masson D, et al. Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma[J]. Br J Cancer, 2009, 101(8): 1417-1424.
[6]Burns PN, Wilson SR. Focal Liver Masses: Enhancement Patterns on Contrast-enhanced Images—Concordance of US Scans with CT Scans and MR Images[J]. Radiology, 2007, 242(1): 162-174.
[7]刘广健，吕明德，谢晓燕，等. 肝细胞性肝癌超声造影表现与肿瘤病理分化关系的研究[J]. 中国超声医学杂志，2006，22（3）：209-212.
[8]霍英杰，袁静，杨景震，等. 3.0T MRI在肝癌随访中检出新发微小癌灶的影像研究[J]. 中国临床医学影像杂志，2014，25（2）：98-102.
[9]李振洲，罗长锐，方凡，等. 乳腺癌超声造影定性及定量分析与p53表达的相关性研究[J]. 中国临床医学影像杂志，2012，23（7）：465-467.
[10]Pei XQ, Liu LZ, Liu M, et al. Contrast-enhanced ultrasonography of hepatocellular carcinoma: correlation between quantitative parameters and histological grading[J]. Br J Radiol, 2012, 85(1017): 740-747.
[11]拉孜，官泳松，次白. 血清P53抗体与原发性肝癌病理分化程度的相关性研究[J]. 西部医学，2011，23（1）：93-95.