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| The clinical research of contrast-enhanced ultrasound in assessment of renal function of diabetic nephropathy |
| ZHAO Li, LI Ming-xing, CHEN Yuan-yuan, LUO Zhi-jian, CHEN Ke-wen |
| Department of Ultrasound Diagnosis, First Affiliated Hospital of Southwest Medical University, Luzhou Sichuan 646000, China |
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Abstract Objective: To investigate the clinical value of contrast-enhanced ultrasound(CEUS) imaging technique in diabetic nephropathy(DN). Methods: Forty-five patients with type 2 diabetes mellitus were divided into group A with DN stages Ⅰ and Ⅱ, group B with DN stage Ⅲ and group C with DN stage Ⅳ. There were fifteen patients in each group. Ten volunteers were enrolled as control group(group N). All subjects underwent CEUS examination, and quantitative analysis was performed on time-intensity curves(TIC) of region of interest. Results: Compared with group N, AUC, TTP, MTT in group A were increased. AUC in group B was increased and in group C was decreased, PI in group B and C were decreased, TTP and MTT were increased, and Grad in group C was increased(All P<0.05). And there were linear correlation between parameters of TIC and indexes of renal function which included UAE, Cr, BUN, UA. Conclusion: CEUS could observe the changes of renal microvascular perfusion of DN in a real-time and dynamic manner, and reflect the extent of the injury of renal function of DN to a certain extent.
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Received: 03 February 2016
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