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| Feasibility of the resting systolic myocardial perfusion imaging to #br#
assess chronic myocardial ischemia using a porcine animal |
| YANG Yi-jing1, HOU Yang1, MA Yue1, ZHANG Xiao-juan2, WANG Yu-ke3, YU Mei4, SUI Shi1 |
1. Department of Radiology, Shengjing Hospital of China Medical University, Laboratory of Medical Image Computing Ministry of Education, Shenyang 110004, China; 2. CT Room, the Third People’s Hospital of Liaoyang, Liaoyang Liaoning 111000, China; 3. Department of Radiology, the People’s Hospital of Liaoning Province, Shenyang 110016, China;
4. Department of Radiology, Tangdu Hospital of the Fourth Military Medical University, Xi’an 710038, China |
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Abstract Objective: To determine the accuracy of the resting systolic myocardial perfusion imaging to assess myocardial ischemia with chronic coronary stenosis and the diagnostic differences capability of the dynamic adenosine-stress CT perfusion using a porcine animal. Methods: The chronic coronary stenosis models was build. 13N-NH3 PET adenosine stress-rest myocardial perfusion imaging(MPI) was obtained in order to have the resting systolic myocardial perfusion imaging(CTP) and the adenosine stress dynamic CT myocardial perfusion imaging(ASDCTP). The myocardial perfusion defect on the resting systolic CTP and ASDCTP were analyzed for the transmural differences in perfusion using the transmural perfusion ratio(TPR) and the myocardial blood flow(MBF) value, respectively. Taking PET-MPI as the reference standard, the sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of CTP in the diagnosis of myocardial perfusion defect segments were evaluated. Using receiver operating characteristic curve(ROC) to assess the value analysis of the resting systolic CTP and ASDCTP. The threshold of significance was P＜0.05. Results: The accuracy of the resting systolic CTP and ASDCTP to detect perfusion abnormalities using PET-MPI as the gold standard were 75.89% and 83.92%; The sensitivity, specificity, PPV and NPV were 68.75%, 81.25%, 73.33%, 77.61% and 83.33%, 84.37%, 80.0%, 87.1%, respectively. The area under the receiver operating characteristic curve(AUC) of the resting systolic and the adenosine stress dynamic CTP were 0.75 and 0.84, respectively, P=0.07(P＞0.05). Conclusion: The resting systolic myocardial perfusion imaging to assess chronic myocardial ischemia using a porcine animal is feasible.
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Received: 01 April 2017
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