进展期胃癌NAC后胃癌周围脂肪组织双能CT碘含量的判断

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Abstract Objective: To explore the value of measuring iodine concentration(IC) in perigastric adipose tissue with dual-energy CT(DECT) for judgment of serosa status after neoadjuvant chemotherapy(NAC). Methods: Thirty-four patients with T4 advanced gastric cancer who underwent DECT before and after treatment were enrolled. According to the postoperative pathologic results, the patients were divided into two groups: the down-staging group(n=10) and the non-down-staging group(n=24). IC(ICPAT) and standardized IC(SICPAT) of perigastric adipose tissue were measured in the two groups, respectively. ROC curve was used to evaluate the capability of SICPAT in detecting serosa invasion. Results: Compared with postoperative pathologic results, the accuracy of judgment of serosa status was 70.59% by conventional CT after NAC. The differences of the changes of ICPAT(△ICPAT) and SICPAT(△SICPAT) between the two groups were statistically significant(P＜0.05). With a △SICPAT threshold of 0.095, area under curve(AUC) was 0.908, the sensitivity, specificity and accuracy for detecting serosa invasion were 90.0%, 83.3% and 85.29%, respectively. Conclusion: The SICPAT in perigastric adipose tissue is an effective indicator to determine the serosa status after NAC and to guide the operation time.

Key words： Stomach neoplasms Tomography, X-ray computed

Received: 31 May 2017

PACS:	Ｒ735.2
	Ｒ814.42

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	YANG Li
	SHI Gao-feng
	LI Yong
	ZHOU Tao

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YANG Li,SHI Gao-feng,LI Yong, et al. Measuring iodine concentration in perigastric adipose tissue with DECT for judgment of serosa status in patients with advanced gastric cancer after NAC[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(4): 273-276.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2018/V29/I4/273

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