Abstract Fat deposition is one of the important pathological processes and intermediate links of numerous diseases, involving its’ occurrence and development. Histopathological examination is the gold standard for evaluating the degree of steatosis quantitatively, but its clinical application is limited due to its own defects, such as invasive, poor reproducibility and differences between observers. Recently, noninvasive magnetic resonance imaging(MRI) for evaluating fat content quantitatively has been developed rapidly and are reviewed in this paper.
MENG Xiang-yu,LI Zi-ying,LI Hui. Magnetic resonance imaging in evaluating fat content quantitatively: a review[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(5): 362-365.
[1]Scheller EL, Rosen CJ. What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health[J]. Ann N Y Acad Sci, 2014, 1311(1): 14-30.
[2]Arai T, Misawa M, Arai M, et al. Accuracy analysis of intrahepatic fat density measurements using dual-energy computed tomography: Validation using a test phantom[J]. J Xray Sci Technol, 2017, 25(3): 403-415.
[3]Festi D, Schiumerini R, Marasco G, et al. Non-invasive diagnostic approach to non-alcoholic fatty liver disease: current evidence and future perspectives[J]. Expert Rev Gastroenterol Hepatol, 2015, 9(8): 1039-1053.
[4]Longo R, Pollesello P, Ricci C, et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis[J]. J Magn Reson Imaging, 1995, 5(3): 281-285．
[5]Longo R, Ricci C, Masutti F, et al. Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography[J]. Invest Radiol, 1993, 28(4): 297-302．
[6]Sharma P, Altbach M, Galons JP, et al. Measurement of liver fat fraction and iron with MRI and MR spectroscopy techniques[J]. Diagn Interv Radiol, 2014, 20(1): 17-26．
[7]Silbernagel G, Kovarova M, Cegan A, et al. High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet[J]. J Clin Endocrinol Metab, 2012, 97(12): E2288-2292．
[8]Vuppalanchi R, Cummings OW, Saxena R, et al. Relationship Among Histologic, Radiologic, and Biochemical Assessments of Hepatic Steatosis[J]. J Clin Gastroenterol, 2007, 41(2): 206-210.
[9]赵爽，李彩英，高凤宵，等. 3.0T 1H-MRS在正常肝脏与脂肪肝的对照研究[J]. 临床放射学杂志，2013，32（2）：202-206.
[10]Di Martino M, Pacifico L, Bezzi M, et al. Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents[J]. World J Gastroenterol, 2016, 22(39): 8812-8819．
[11]Justesen J, Stenderup K, Ebbesen EN, et al. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis[J]. Biogerontology, 2001, 2(3): 165-171.
[12]唐小彬，赵振国，文峰，等. 绝经后女性腰椎骨髓脂肪含量与腹内脂肪组分相关性研究[J]. 医学影像学杂志，2016，26（9）：1694-1697.
[13]Cohen A, Shen W, Dempster DW, et al. Marrow adiposity assessed on transiliac crest biopsy samples correlates with noninvasive measurement of marrow adiposity by proton magnetic resonance spectroscopy(1H-MRS) at the spine but not the femur[J]. Osteoporos Int, 2015, 26(10): 2471-2478.
[14]郭达，杨陈，陈天武，等. 脂肪肝的MRI研究进展[J]. 西部医学，2017，29（4）：574-581.
[15]Cotler SJ, Guzman G, Layden-Almer J, et al. Measurement of liver fat content using selective saturation at 3.0T[J]. J Magn Reson Imaging, 2007, 25(4): 743-748.
[16]李文政，彭光春，汤恢焕，等. 脂肪肝CT、MRI定量诊断的对照实验研究[J]. 医学影像学杂志，2005，15（4）：294-297.
[17]Mart ERLI, Sentis M, Puig J, et al. Comparison of in-phase and opposed-phase GRE and conventional SE MR pulse sequences in T1-weighted imaging of liver lesions[J]. J Comput Assist Tomogr, 1996, 20(6): 890-897.
[18]王斐斐，程敬亮，王松，等. 三点法 Dixon水脂分离成像对肾错构瘤的诊断价值[J]. 肿瘤基础与临床，2016，29（2）：150-153.
[19]Zhang L, Li S, Hao S, et al. Quantification of fat deposition in bone marrow in the lumbar vertebra by proton MRS and in-phase and out-of-phase MRI for the diagnosis of osteoporosis[J]. J Xray Sci Technol, 2016, 24(2): 257-266.
[20]石喻，郭启勇，夏菲，等. 同反相位图像减影技术及T2校正1H-MRS定量分析非酒精性脂肪肝的临床研究[J]. 中国临床医学影像杂志，2012，23（4）：248-252.
[21]Reeder SB, Pineda AR, Wen Z, et al. Iterative decomposition of water and fat with echo asymmetry and least-squares estimation(IDEAL): application with fast spin-echo imaging[J]. Magn Reson Med, 2005, 54(3): 636-644．
[22]Reeder SB, Wen Z, Yu H, et al. Multicoil Dixon chemical species separation with an iterative least-squares estimation method[J]. Magn Reson Med, 2004, 51(1): 35-45．
[23]Nardo L, Karampinos DC, Lansdown DA, et al. Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI[J]. J Magn Reson Imaging, 2014, 39(5): 1178-1185.
[24]Bogunovic L, Lee SX, Haro MS, et al. Application of the Goutallier/Fuchs Rotator Cuff Classification to the Evaluation of Hip Abductor Tendon Tears and the Clinical Correlation With Outcome After Repair[J]. Arthroscopy, 2015, 31(11): 2145-2151.
[25]Takasu M, Kaichi Y, Tani C, et al. Iterative decomposition of water and fat with echo asymmetry and least-squares estimation(IDEAL) magnetic resonance imaging as a biomarker for symptomatic multiple myeloma[J]. PLoS One, 2015, 10(2): e0116842．
[26]Meisamy S, Hines CD, Hamilton G, et al. Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy[J]. Radiology, 2011, 258(3): 767-775．
[27]Pichardo JC, Milner RJ, Bolch WE, et al. MRI measurement of bone marrow cellularity for radiation dosimetry[J]. J Nucl Med, 2011, 52(9): 1482-1489．
[28]焦志云，李澄，何玲，等. 运用3.0T磁共振IDEAL-IQ技术进行肝脏脂肪定量分析的可行性研究[J]. 中华临床医师杂志，2015，9（19）：3516-3520.
[29]Aoki T, Yamaguchi S, Kinoshita S, et al. Quantification of bone marrow fat content using iterative decomposition of water and fat with echo asymmetry and least-squares estimation(IDEAL): reproducibility, site variation and correlation with age and menopause[J]. Br J Radiol, 2016, 89(1065): 20150538．
[30]王晓敏，张晓晶，马林，等. 磁共振量化评价非酒精性脂肪肝脂肪含量的研究进展[J]. 医疗卫生装备，2016，37（4）：128-131.
[31]Cordes C, Baum T, Dieckmeyer M, et al. MR-Based Assessment of Bone Marrow Fat in Osteoporosis, Diabetes, and Obesity[J]. Front Endocrinol(Lausanne), 2016, 7: 74.
[32]Rehm JL, Wolfgram PM, Hernando D, et al. Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women[J]. Eur Radiol, 2015, 25(10): 2921-2930.
[33]Kühn JP, Berthold F, Mayerle J, et al. Pancreatic Steatosis Demonstrated at MR Imaging in the General Population: Clinical Relevance[J]. Radiology, 2015, 276(1): 129-136.
[34]Idilman IS, Tuzun A, Savas B, et al. Quantification of liver, pancreas, kidney, and vertebral body MRI-PDFF in non-alcoholic fatty liver disease[J]. Abdom Imaging, 2015, 40(6): 1512-1519．
[35]陈慧莹，袁慧书. 磁共振脂肪定量技术在骨骼疾病中的应用与展望[J]. 磁共振成像，2014，5（2）：150-155.
2018, Vol. 29 
