新生猪缺氧缺血性脑损伤后基底节区Tau蛋白与谷氨酸变化的相关研究

doi:DOI:10.12117/jccmi.2018.08.004

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Abstract Objective: To investigate the Tau protein expression and glutamate(Glu) characteristics in basal ganglia following hypoxic-ischemic(HI) reperfusion brain injury in a piglet model, further defined the Tau protein and Glu in the role of HI brain injury mechanism. Methods: A total of 45 healthy piglets(3~5 days old, 1.0~1.5 kg) were divided into control(n=9) and hypoxic-ischemic(HI) model groups(n=36). The HI model group was further divided into six groups according to 1H-magnetic resonance spectroscopy(1H-MRS) scan times after HI(0~2 h, 2~6 h, 6~12 h, 12~24 h, 24~48 h and 48~72 h). Measure Tau protein and Glu at different time points after HI in basal ganglia and the correlation of Tau protein and Glu, P<0.05 considered statistically significant, the decimal to 2 digits. Results: The results of 1H-MRS showed that after HI, the Tau protein content increased first, then decreased, and reached the highest point in 24~48 h, which was statistically different from the control group. Glu appears to rise first, then decreases, then rises again, showing a “bimodal” change, which peaks at 6~12 h and 24~48 h. Tau protein and Glu were positively correlated, correlation coefficient r=0.76(P<0.05). Conclusions: These results indicate that after HI, Tau protein and Glu work together on the neural networks and neurons and glial cells in the brain.

Key words： Brain injuries tau proteins Glutamic acid Swine, miniature Magnetic resonance imaging

Received: 10 May 2018

PACS:	Ｒ651.15
	Ｒ445.2

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	ZHENG Yang
	WANG Xiao-ming

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ZHENG Yang,WANG Xiao-ming. Study of relationship between Tau protein changes and glutamate expression in basal ganglia after hypoxic-ischemic reperfusion injury in piglets[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(8): 543-547.

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http://www.jccmi.com.cn/EN/DOI:10.12117/jccmi.2018.08.004 OR http://www.jccmi.com.cn/EN/Y2018/V29/I8/543

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