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| The value of ADC and DCE-MRI in differentially diagnosing of primary central nervous system lymphoma and demyelinating pseudotumor |
| CHEN Chen, REN Cui-ping, ZHAO Rui-chen, CHENG Jing-liang, WEN Bao-hong |
| Department of MR, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China |
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Abstract Objective: To assess the value of ADC and DCE-MRI in differentially diagnosing of primary central nervous system lymphoma and demyelinating pseudotumor. Methods: A total of 35 cases of PCNSL and 11 cases of the DPT confirmed by pathology were analyzed retrospectively. All of patients underwent MR scans which were obtained ADC and DCE-MRI data. Age, gender, ADC, TIC, SImax, Tmax, and MCER were measured and compared between PCNSL and DPT. The diagnostic efficacy of ADC and DCE-MRI were calculated. Two independent samples t tests, t’ test, chi-square test and Wilcoxon rank sum test were used to do statistically. Results: The ADC value((0.75±0.22)×10-3 mm2/s), MCER((115.74±7.71)%) of 35 cases of PCNSL were statistically different from 11 cases of the DPT((1.25±0.05)×10-3 mm2/s, (32.57±3.81)%). The cut-off value of ADC and MCER were respectively 1.03×10×10-3 mm2/s and 226.7% in differential diagnosis of PCNSL and DPT. There were 3 type Ⅰ TICs, 10 type Ⅱ TICs, 22 type Ⅲ TICs in 35 cases of PCNSL. There were 2 type Ⅰ TICs, 2 type Ⅱ TICs, 7 type Ⅲ TICs in 11 cases of the DPT. The age, gender, SImax, Tmax and EER were not statistically different between the two tumors(P>0.05). Conclusion: The ADC value of PCNSL is less than DPT’s; MCER of PCNSL is greater than DPT’s, and MCER is more valuable than ADC, and these parameters can help diagnosis.
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Received: 15 January 2018
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