超声造影结合定量分析法诊断甲状腺微小乳头状癌的临床价值

doi:DOI:10.12117/jccmi.2019.04.007

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Abstract Objective: To explore the value of CEUS combined with quantitative analysis in the diagnosis of papillary thyroid microcarcinoma(PTMC). Methods: The CEUS features of 63 solid thyroid nodules(diameter≤10 mm) were retrospectively analyzed. The peak intensity(PI), the rise time(RT), the mean transit time(MTT), the area under the curve(AUC), the time from peak to one half(TPH), the time to peak(TTP), the wash in slope(WS) of nodules were quantitatively analyzed by QLAB software, all nodules were confirmed by surgery and pathology. Results: There was a difference between PTMC and benign small thyroid nodules in enhancement patterns(χ2=33.542, P=0.000). The sensitivity and specificity of early hypo-enhancement or hypo-enhancemen in the diagnosis of PTMC were 82.82% and 79.40% respectively. PI in PTMC was lower than that in tissues surrounding thyroid malignant nodules, benign small nodules of thyroid and tissues surrounding benign small nodules, and the difference was statistically significant(P<0.05). The PI of thyroid benign nodules was lower than that of tissues surrounding the benign nodules, and the difference was statistically significant(P<0.05). The AUC, TTP and WS of PTMC were lower than those of tissues surrounding the benign nodules(P<0.05). There was no significant difference in other groups(P>0.05). The sensitivity and specificity of PI in the diagnosis of PTMC were 86.21% and 88.23% respectively. Conclusion: The main perfusion mode of PTMC was early hypo- or hypo-enhancement. PI is the most valuable quantitative parameter of ROI, which can be used as an important reference index for differentiating benign and malignant thyroid nodules. Quantitative parameters such as RT, MTT, AUC, TPH, TTP and WS have little value in differentiating benign and malignant thyroid nodules.

Key words： Thyroid neoplasms Carcinoma, papillary Ultrasonography

Received: 02 May 2018

PACS:	Ｒ736.1
	Ｒ730.261
	Ｒ445.1

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	Articles by authors
	LIANG Li-ping
	REN Hai-bo
	ZHENG Yan-fen
	WU Cai-hong

Cite this article:

LIANG Li-ping,REN Hai-bo,ZHENG Yan-fen, et al. Clinical value of CEUS combined with quantitative analysis in the diagnosis of papillary thyroid microcarcinoma[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(4): 253-256.

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http://www.jccmi.com.cn/EN/DOI:10.12117/jccmi.2019.04.007 OR http://www.jccmi.com.cn/EN/Y2019/V30/I4/253

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