JOURNAL OF CHINA MEDICAL IMAGING

Office Online

Journal Online

Advanced Search

期刊信息

创刊日期：1990年
主管单位：中国人民共和国卫生部
主办单位：中国医学影像技术研究会
　　　　　中国医科大学
承办单位：中国医科大学附属盛京医院
　　　　　辽宁省医学影像学会
编辑出版：《中国临床医学影像杂志》
　　　　　编辑部
刊　　期：月刊

2017 Vol. 28, No. 5 Published: 2017-05-20

	305	Dorsolateral putaminal abnormality on magnetic resonance imaging in differentiating#br# parkinsonism-predominant multiple system atrophy from Parkinson’s disease
		ZHENG Kui-hong1, QI Xiao-kun2, LIU Jian-guo2, GUO Yong2, HUANG Min-hua2, MA Lin1
		Abstract: Objective: To evaluate the diagnostic value of dorsolateral putaminal abnormality on magnetic resonance imaging(MRI) for differentiating parkinsonism-predominant multiple system atrophy(MSA-p) from Parkinson's disease(PD). Methods: Teen patients with MSA-p, 20 patients with PD were included. All subjects were examined with 3.0T MRI using the conventional and diffusion-weighted protocol. Putaminal atrophy, hypointensity on diffusion-weighted imaging(DWI) associated with a slit-like T2-hyperintense rim on the dorsolateral putamen were evaluated in each item. Results: Putaminal atrophy was found in 60% (6 of 10) of the MSA-p group, in only 10%(2 of 20) of the PD group. Dorsolateral putaminal abnormalities were seen in MSA-p(n=8) group, and none in PD group. The slit-like T2-hyperintense rim and the hypointensity on DWI in the dorsolateral putamen were seen in 80%(8/10) of the MAS-p group, which is significantly higher than PD group(0/20). The specificity and sensitivity of the dorsolateral putaminal abnormality for distinguishing MSA-p from PD was 100% and 80%, respectively. Conclusions: The signal changes including slit-like T2-hyperintense rim associated with hypointensity on DWI in the dorsolateral putamen are specific signs for differentiating MSA-p from PD.
		2017 Vol. 28 (5): 305-308 [Abstract] ( 833 ) HTML (1 KB) PDF (0 KB) ( 146 )

	309	Combined with SWI and 3D-PCASL in prediction of bleeding after acute cerebral infarction
		XU Kai-xi, FENG Guang-kui, MA Xian-jun, CHEN Xin-jian, ZUO Tao-sheng, BIAN Guang-rong,
		Abstract: Objective: To evaluate the clinical value of combined using 3.0T magnetic resonance magnetic susceptibility weighted imaging(SWI) and three dimensional pseudo continuous arterial spin labeling(3D-PCASL) in prediction of hemorrhagic transformation(HT) after acute cerebral infarction. Methods: Fifty-four cases of acute cerebral infarction(<72 h) were performed conventional MRI, 3D-PCASL and SWI. The SWI were used to assess the type of HT. Combined with SWI and 3D-PCASL, the infarction area, HT area and cerebral blood flow(CBF) of each patient were calculated and the correlation relationship among them were analyzed. Results: In 54 cases of acute cerebral infarction, 19 cases were HT, 13/19 cases were HI type, 6/19 cases were PH type. The average rCBF zone in HI or PH lesions and area around two types of the lesions were (32.787±10.876), (26.655±19.325), (26.033±10.930), (28.984±11.019) mL/(100g·min), the differences of rCBF in HI and PH lesions area difference was statistically significant(t=0.766, P=0.000, <0.01, t=0.834, P=0.041, <0.05). Within and around the 54 cases of acute cerebral infarction lesions, the high perfusion hemorrhage presented in 42.8% and 50% lesions, respectively. Normal perfusion and surrounding hemorrhage presented in 50% and 37.5% of lesions, respectively. Hypo-perfusion and the surrounding hemorrhage presented in 31.7% and 28.1% lesions, respectively. Acute cerebral infarction and HT lesion area and the surrounding low, normal, high perfusion of the t test analysis statistically significant(t=0.658, P=0.002, <0.01). Conclusion: Combined the SWI and 3D-PCASL is useful in prediction of HT after acute cerebral infarction.
		2017 Vol. 28 (5): 309-314 [Abstract] ( 800 ) HTML (1 KB) PDF (0 KB) ( 388 )

	315	Clinical application value of susceptibility weighted imaging in diagnosing arterial thrombosis in#br# acute cerebral infarction
		ZHANG Bing1, LIU Jun2, LIAN Kai-xi3, XU Liang2, HAO Cai-xian2, DONG Long-chun2
		Abstract: Objective: To discuss the clinical application value of susceptibility weighted imaging(SWI) in diagnosing arterial thrombosis, evaluating the condition and prognosis of patients in acute cerebral infarction. Materials and Methods: Thirty-two cases of acute cerebral infarction were imaged with conventional MRI, DWI, MRA and SWI. All patients underwent MR imaging using 3.0T MRI system. Using SWI-mIP to display arterial thrombosis. Define susceptibility vessel sign(SVS) as an arterial thrombosis is positive on SWI. The relationship among SVS and infarction area, clinical scores and shot-term prognosis were calculated respectively. Result: in 32 cases, 16 cases showed SVS sign. The positive rate of SVS was 50%(16/32), consisted with the lesions region of MRA and mainly occured in proximal of middle cerebral artery. The acute infarction area with SVS positive was greater than the SVS negative, there had statistically difference(P<0.05). SVS displayed on SWI was associated with NIHSS scores, shot-term prognosis(P<0.05). Conclusion: SWI is useful for assessment in arterial thrombosis, providing objective imaging evidences for the choice of clinical treatment and the evaluation condition and prognosis of patients in acute cerebral infarction. SWI can be used routinely in patients with acute cerebral infarction.
		2017 Vol. 28 (5): 315-317 [Abstract] ( 880 ) HTML (1 KB) PDF (0 KB) ( 180 )

	318	Amplitude low-frequency oscillation abnormalities in trigeminal neuralgia patients
		YAN Jian-hao, WANG Tian-yue, LI Meng, LI Chao, XIA Li-kun, YIN Yi, ZHAN Wen-feng, JIANG Gui-hua
		Abstract: Objective: To explore the regional spontaneous activity changes in the whole brain of trigeminal neuralgia(TN) patients using resting-state fMRI. Methods: Resting-state fMRI datasets of 30 TN patients and 20 healthy controls were acquired. The amplitude low-frequency fluctuation(ALFF) and independent-sample t-test were used to compare the brain activity abnormalities between these two groups. Results: In TN patients, we found decreased ALFF in the left superior temporal gyrus and left fusiform, as well as an increased ALFF in the left frontal med orb and left sup motor area. Conclusion: Our results demonstrated the spontaneous activity change underlying TNP, and these abnormalities may contribute to the cognization and emotion of the pain.
		2017 Vol. 28 (5): 318-320 [Abstract] ( 736 ) HTML (1 KB) PDF (0 KB) ( 192 )

	321	The application of shear wave elastography in the evaluation of type A botulinum toxin injection#br# masseter for face-lift
		DIAO Xue-hong, GUO Yu, CHEN Yue, JIN Jia-mei, CHEN Lu, ZHAN Jia
		Objective: To assess the value of shear wave elastography(SWE) in the evaluation of type A botulinum toxin injection masseter for face-lift. Methods: 20 patients injected type A botulinum toxin in masseter. All the patients were examined by two-dimensional ultrasound and SWE. These two imagine methods measured the thickness and hardness of masseter under the relaxation state and forced occlusal status before injection, and after 1 week, 1 month, 3 months, 6 months. Result: Started 1 week after injection of type A botulinum toxin, the thickness and hardness of masseter muscle were decreased under both relaxation and occlusal condition. Those changes were obvious at 3 months, the mean reduction of relaxation masseter muscle thickness were 22.2%±4.2%, contraction thickness were 22.8%±5.3%, muscle strength was also significantly decreased, the mean reduction of relaxation strength were 19.5%±3.4%, contraction strength were 60.4%±5.8%, the thickness and hardness began to recover on 6 month. Conclusion: SWE and B-ultrasound could effectively reflect the reduction of muscle thickness and herdness after type A botulinum toxin injection. It could provide the best time and dose reference for the second injection.
		2017 Vol. 28 (5): 321-323 [Abstract] ( 751 ) HTML (1 KB) PDF (0 KB) ( 143 )

	324	Preliminary investigate on the application value of the ultrasonic classification in breast sclerosing adenosis
		CAI Qing-yuan, XIE Si-pei
		Objective: To investigate the classificatory value of color doppler ultrasonography in breast sclerosing adenosis(SA). Methods: Preoperative sonography of 23 SA patients(pathological confirmed) from January 2010 to December 2015 were retrospectively analyzed. SA lesions were classified as localized sclerosing adenosis(LSA) or tuberous sclerosing adenosis(TSA). Results: ①The average age of LSA group was younger than TSA;②21.74% SA patients were misdiagnosed as malignant lesions; ③The detective rates of acoustic halo, focal calcification and the internal blood flow between two SA groups had no statistical significant differences(P=0.812, 0.584, 0.606, P>0.05). Meanwhile, there were statistical significant differences in internal echo, shape and margin border between two SA groups(P=0.000, 0.000, 0.001, 0.034, P<0.05). Conclusion: Further analyzation of characteristic signs from color Doppler ultrasonography is useful in classification of LAS and TAS.
		2017 Vol. 28 (5): 324-326 [Abstract] ( 786 ) HTML (1 KB) PDF (0 KB) ( 167 )

	327	MRI features of different molecular subtypes of breast cancer
		SUN Shuang-yan, YANG Chang-liang, HUANG Zhi-cheng, NAN Ying-ji, SUI Chang-ping, ZHAO Ji-hong
		Objective: To explore the MRI features of different molecular subtypes of breast cancer. Materials and Methods: Pre-operation breast MR images of 139 patients were retrospectively investigated concerning strengthen way, morphological, internal and marginal characteristics of mass like enhancement, time-signal intensity curve types and accompanied signs. Meanwhile, expression levels of immunohistochemistry indices including ER, PR, HER-2 and Ki-67 were recorded, and all subjects were assigned to different groups based on their molecular subtypes: Luminal A, Luminal B, HER-2 positive and TNBC. Differences in MRI characteristics were compared and tested with χ-square test, relevance between MRI characters and molecular subtyping was analyzed by crosstab analysis. Results: N of each group: Luminal A(32), Luminal B(76), HER-2 positive(14), TNBC(17). A total of 119 were mass like enhancement, whereas 20 were non-mass like enhancement. Among the mass like enhancement, the molecular subtype was slight correlated with margin(C=0.360, P=0.008) and time-signal intensity curve type(Ｃ=0.318, P=0.019）, moderately correlated with internal enhancement characteristics(C=0.442, P=0.001), whereas morphology and accompanied signs were not relevant to molecular subtype(C=0.065, P=0.791). Conclusions: Different subtypes of breast cancer showed distinct MRI manifestations, molecular subtyping was partially relevant to MRI characters. Thus, pre- operation MRI is helpful in preliminary determination of prognosis and preliminary preparation of therapeutic plans.
		2017 Vol. 28 (5): 327-330 [Abstract] ( 973 ) HTML (1 KB) PDF (0 KB) ( 170 )

	331	The features of breast cancer in young women and the diagnostic efficacy of imaging means
		LIU Dan-qing1, ZHANG Wei1, WANG Hui-ying1, HAN Lu2, LV Dong-jun1
		Objective: This is a retrospective study which analyzed the clinical, pathological and radiological information of young women with pathological confirmed breast cancer(≤35 years) in the past four years in our hospital to evaluate the diagnostic value of various imaging methods. Methods: Retrospective analyzed 174 patients(under 35 years old) with 180 pathological confirmed breast cancer lesions in our hospital from January 2011 to December 2014(the average age was 31.6). All patients underwent ultrasound, and 89/174 patients underwent pre-operation mammography, and 21/174 underwent dynamic contrast-enhanced MRI. The status of first clinical symptoms, pathological type, immunohistochemically result, lymph node metastasis, breast imaging performance characteristics, the classification of Breast Imaging Reporting Data System were analyzed. Results: The majority clinical symptom of breast cancer in young women is breast masses which were found occasionally or by health examination(94/174, 54.0%). The main histological type is invasive ductal carcinoma(148/180, 82.2%), and Ⅱ/Ⅲ grade carcinoma accounted for majority of invasive ductal carcinoma(118/148, 79.7% and 20/148, 13.5%). Axillary lymph node-positive rate is high(55/140, 39.3%). Immunohistochemical results showed that the expression level of hormone receptor is low, 36.2% of breast cancer expressed estrogen receptor negative(63/174), 33.3% of breast cancer expressed progesterone receptor negative(58/174); 58.6% of breast cancers was Luminal A type(82/140). Mammography findings maily performed as mass (or with calcification)(52/78, 66.7%), with high density, irregular, blurred edges. The sensitivity and specificity of the breast ultrasound are 100% and 97.1%, respectively and of mammography are 96.6% and 87.6%, respectively, and of dynamic contrast-enhanced breast MRI are both 100%. Conclusions: Breast cancer in young women usually showed breast masses with no symptoms as the main clinical manifestation. The main pathologic type is high-level(Ⅱ, Ⅲ grade) invasive ductal carcinoma, with high lymph node metastasis rate, high ER, PR negative rate, and majority immunohistochemistry type of breast cancer is Luminal A type. The main characteristics of breast cancer mammography images are irregular shape, blurred edge and high density mass(with calcification). The sensitivity and specificity of breast ultrasound is relatively high, which should be taken as the main screening tool for breast cancer in young women. When faced with suspected malignant lesions, joint applying two or more imaging approaches could improve the specificity of diagnosis and avoid unnecessary biopsies and surgery.
		2017 Vol. 28 (5): 331-336 [Abstract] ( 965 ) HTML (1 KB) PDF (0 KB) ( 168 )

	337	A preliminary study on the time-intensity curve in the differentiation of triple-negative breast cancer
		HUANG Xiao-li, WANG Xiao-yan, LIU Chun-lin
		Objective: To explore the value of time-intensity curve(TIC) of contrast-enhanced in differentiation of triple-negative breast cancer(TNBC). Methods: TIC analysis were performed in 126 patients with 126 breast lesions and its surrounding tissue. Pathology and immunohistochemical staining used as the golden diagnostic criteria. Results: Contrast intensity and area under curve of TNBC lesions were larger than that of non-TNBC(P<0.001). And their area under the ROC curve was 0.857 and 0.807 respectively. We considered that when the parameter of contrast intensity>11.99, the lesions are prone to be TNBC(sensitivity 88%, specificity 80%), when the parameter of area under curve>684.31, the lesions are prone to be TNBC(sensitivity 60%, specificity 95%). The base intensity of surrounding tissue in TNBC group was lower, and the contrast intensity was larger, while comparing with the surrounding tissue in non-TNBC group. Compared with the surrounding tissue, the peak intensity, contrast intensity, ascending slope and half time of the lesions in the TNBC group were significantly higher than those in the surrounding tissue(P<0.05). With the different from non-TNBC, there was no significant difference in the arrive time, peak time and base intensity compared with the surrounding tissues. Conclusion: The quantitative analysis of TIC can help to differentiate TNBC from non-TNBC to a certain extent.
		2017 Vol. 28 (5): 337-340 [Abstract] ( 864 ) HTML (1 KB) PDF (0 KB) ( 343 )

	341	Study on using spectral CT technology for improving imaging quality of portal venography in cirrhosis
		HUANG Rui-sui, DING Ke, YIN Hua, WEI Xue, ZHAO Qin-ping, HE Fei
		Objective: To investigate the effect of spectral CT technology for improving imaging quality of portal venography in cirrhosis patients. Methods: 42 patients with cirrhosis underwent enhanced CT scans spectral CT mode in the portal phase and conventional helical mode in other phase. The best contrast-to-noise ratio(CNR) for main portal veins, as well as the conventional polychromatic images were obtained in the portal phase, and volume rendering and maximum intensity projection were created to show the portal veins. CT value of the main portal vein, liver parenchyma and image noise were measured. Overall imaging quality were assessed by two radiologists with more than 10 years’ experience of abdominal imaging diagnosis. Comparison between the two groups by using independent-samples t test. Inter-observer agreement in subjective image quality was assessed by Kappa statistics. Results: The monochromatic images at 50~53 keV were found to have the best CNR for portal veins. CT value of the main portal vein and liver parenchyma, the image noise and the CNR of optimal monchromatic images were statistically significantly higher than that of polychromatic images, respectively(P<0.01). In the comparison of image quality, the optimal monochromatic reconstructed images(Kappa value=0.759) were higher than polychromatic reconstructed images(Kappa value=0.521). The image quality scores of two groups were 4.17±0.72 and 3.06±0.55. There were significant differences between the image quality scores of two groups(P<0.01). Conclusion: Monochromatic images of spectral CT could improve CNR for display portal veins and improve the image quality.
		2017 Vol. 28 (5): 341-344 [Abstract] ( 1065 ) HTML (1 KB) PDF (0 KB) ( 153 )

	345	Preliminary application of dual-energy dual-source CT virtual non-contrast imaging in#br# inflammatory bowel diseases
		LAN Xing1, TANG Hao2, ZHOU Fan3, ZHOU Chang-sheng2, HUANG Wei2
		Objective: To assess the clinical feasibility of dual-source CT enterography using dual-energy virtual non-contrast(VNCT) imaging in diagnosis of inflammatory bowel diseases. Materials and Methods: The dual-energy dual-source CT enterography data from a cohort of 37 inflammatory bowel disease patients(31 Crohn’s disease and 6 ulcerative colitis), who were confirmed by clinical settings, were analyzed retrospectively. All the patients underwent abdominal conventional non-enhanced CT scan(CNCT) as well as arterial and venous phase dual-energy enhanced scan(100 kVp/210 mAs and Sn140 kVp/162 mAs). VNCT images of arterial and venous phase were obtained using the dual-energy software. The differences of image quality, radiation dose and diagnostic coincidence rate between the true non-contrast scan and VNC images were compared. Results: Compared with CNCT images, all the inflammatory bowel segments were detected accurately by VNCT images, and there was no significant difference of size and extent of lesions between the CNCT and VNCT. All the VNCT images met the requirement of diagnosis, and the differences of intestinal wall thickness, intestinal wall edema or effusion, intestinal morphology and lymph node size were no significant. The noise level of images obtained from VNC was lower than that of the real non-contrast scan(P<0.05), with higher SNR(P<0.05). There was no significant difference of image scoring among the three groups(P>0.05). There was no statistic difference of the radiation dose of conventional non-enhanced CT, arterial and venous phase CECT. The radiation dose of two-phase dual-energy scan was 32.97% lower than that of the conventional threephase scans. Conclusion: For inflammatory bowel diseases, the virtual non-contrast images obtained from the dual-energy CT scan can effectively reduce the radiation dose, decrease radiation injury, and meet the needs of clinical diagnosis.
		2017 Vol. 28 (5): 345-349 [Abstract] ( 961 ) HTML (1 KB) PDF (0 KB) ( 139 )

	350	A preliminary study on predicting the prognostic high-risk factors of cervical squamous cell carcinoma after neoadjuvant chemotherapy by CT perfusion imaging
		YIN Liang, LEI Jun-qiang, GUO Ji-gang, ZHAI Ya-nan, DOU Yu
		Objective: To explore the predictive value of CT perfusion imaging for predicting the prognostic high-risk factors of cervical squamous carcinoma after neoadjuvant chemotherapy. Methods: The 51 patients who had cervical squamous carcinoma and underwent neoadjuvant chemotherapy before surgery between 2011 May and 2015 August in the First Hospital of Lanzhou University were selected. Based on the prognostic high-risk factors of pathology test and short-term prognosis, the cases were divided into two groups: non-high-risk factors(n=36, 70.59%) and high-risk group(n=15, 29.41%). CT perfusion parameters and clinical data were retrospectively analyzed to investigate the high-risk prognostic factors. Results: Two indexes of the high-risk group cases, the BF(blood flow) and the maximum diameter of the tumor post chemotherapy, were statistically significant higher than another group(P<0.05). The high-risk prognostic factors were positively correlated with BF and the maximum diameter of tumor after neoadjuvant chemotherapy(r=0.420, P=0.002; r=0.296, P=0.035). FIGO staging, pathological grade, the initial diameter of the tumor, BV, permeability and TTP were not correlated with the high-risk prognostic factors(P>0.05). Multivariate logistic regressionn analysis showed BF was an independent predictor to predict the existence of high-risk prognostic factors in cervical squamous carcinoma after neoadjuvant chemotherapy. BF can predict the?prognostic results accurately AUC=0.810, P=0.001, 95%CI(0.682~0.918). Conclusion: BF had significant predictive value as a prognostic high-risk factor of cervical squamous carcinoma after neoadjuvant chemotherapy. Using BF equal to or greater than 46.64 mL/(100mL·min) to predict the existence of high-risk prognostic factors got 86.67%(13/15), 94.44%(34/36) and 92.16%(47/51) in sensitivity, specificity and accuracy, respectively.
		2017 Vol. 28 (5): 350-353 [Abstract] ( 700 ) HTML (1 KB) PDF (0 KB) ( 250 )

	354	A X-ray analysis of 2 196 ankle fractures cases in adults
		WANG Yong1, SHI Liang2, CAO Lei2, WU Wen-juan2, CUI Zhi-gang3
		Objective: Analysis of clinical epidemiology characteristics of ankle fractures in adults, including fracture types and its distribution. To explore the relationship between these fractures and its mechanism of injury, and analysis of misdiagnosis of fracture and missed diagnosis. Methods: From January 2013 to December 2015 newly diagnosed adult patients with ankle fractures in the Third Hospital of Hebei Medical University were included in our research. The Danis-Weber Classification and Lauge-Hansen Classification were used to classify these fractures. Results: A total of 2 196 cases of ankle fractures, among them Weber type A accounted for 30%, Weber type B accounted for 42%, Weber type C accounted for 20%, vertical compression fractures accounted for 8%, 16~50 years old men accounted for 39%, women over 50 years of age accounted for 22%. There were 13 cases of missed diagnosis. The posterior malleolus, upper fibula and the lower front part of the tibia are prone to missed the fracture diagnosis. The missed diagnosis rate was 1.1%. Conclusion: Young men and older women have a relatively high preference for ankle fractures. Danis-Weber classification combined with Lauge-Hansen classification can help doctors to analyze the mechanism of injury and may predict the range of fractures involved. Thereby reduce the missed diagnosis of factures and improve the diagnostic accuracy.
		2017 Vol. 28 (5): 354-358 [Abstract] ( 984 ) HTML (1 KB) PDF (0 KB) ( 171 )

	359	Evaluation of abnormalities of the shoulder rotator cuff in patients with type 2 diabetes mellitus by#br# two-dimensional high-frequency ultrasonography and power Doppler imaging
		TAO Wen-hui, ZHANG Yu-hong, ZHANG Ping, SU Ben-li
		Objective: To evaluate the value of two-dimensional high-frequency ultrasonography and power Doppler imaging for judgement of the abnormalities of the shoulder rotator cuff in patients with type 2 diabetes mellitus(T2DM). Methods: A total of 60 T2DM patients were enrolled and divided into two groups: group B(30 cases, the course≤10 years), group C(30 cases, the course>10 years). 30 healthy subjects were enrolled in group A as normal control. The echotexture of the shoulder rotator cuff and blood flow were observed by two-dimensional high-frequency ultrasonography and power Doppler imaging. The thickness of the long head of the Biceps(BT), Subscapularis tendon(SUB), Supraspinatus tendon(SUP) and Infraspinatus tendon(INF) were measured. Results: The ultrasound imaging of each normal tendon was displayed as string like homogeneous hyperechogenicity interrupted by thin hypoechogenicity in longitudinal section. The abnormal ultrasound findings, such as hypoechoic areas, heterogenous echogenicity, or irregular edges, were more frequently detected in group B than group A of SUP, as well as in group C of BT, SUP, SUB and INF(P<0.05). The ratio of calcification of group B and group C was larger than that of group A(P<0.05). The ratios of abnormalities of the surrounding tissue in BT of group C was larger than that of group A(P<0.05). In both sides, the thicknesses of each tendon in group B and group C were greater than those of group A(P<0.05), and the thicknesses of BT and SUP in the dominant side in group C were greater than those of group B(P<0.05). The thickness of BT in group C were greater in the dominant side than that in the other side(P<0.05). There were no significant difference among the groups of A, B and C in gradings of blood flow. Conclusion: The abnormal echotextures, thickness and internal blood flow of the shoulder rotator cuff in the patients of T2DM can be evaluated by two-dimensional high-frequency ultrasonography and power Doppler imaging objectively.
		2017 Vol. 28 (5): 359-362 [Abstract] ( 594 ) HTML (1 KB) PDF (0 KB) ( 133 )

	363	The molecular imaging research of chemokine receptor 4(CXCR4)
		CAO Xue-liang1, FU Peng2, JIANG Ting-jun1, LUAN Sha1, ZHAO Chang-jiu1
		Objective: To investigate the possibility of using small interference RNA(siRNA) targeting human chemokine receptor 4(CXCR4) radiolabeled with 99mTc for diagnosing human breast cancer. Methods: Small interference RNA targeted to CXCR4 mRNA and negative control siRNA were synthesized and radiolabeled by 99mTc with the bifunctional chelator HYNIC. The labeling efficiency, radiochemical purity and stability were investigated. Animal models of nude mice bearing human breast cancer MDA-MB-231 were established, divided them into three groups, 10 mice in each group. 99mTcO4-, 99mTc-HYNIC- siRNA(interference group), 99mTc-HYNIC-siRNA(negative control group) were separately injected through tail vein to the three groups. After 99mTcO4-, 99mTc-HYNIC-siRNA(interference group), 99mTc-HYNIC-siRNA(negative control group) were introduced into these animal models, tumor images were acquired with SPECT, the ratio of T/M was calculated. The data were analyzed by two-sample t test and analysis of variance. Results: The labeling efficiency of siRNA(interference group) and siRNA(negative control group) were (61.26±2.47)% and (60.85±2.76)% respectively. The radiochemical purities were both above 90%. Incubated in fresh human serum and PBS for 30 min and 120 min at 37℃, respectively, probes’ properties remained stable in 2 hours. At 1, 4 and 10 h after injection of different probes, the T/M ratios of 99mTc-HYNIC-siRNA(interference group) were 3.486±0.145, 4.574±0.222 and 6.608±0.366, and that of 99mTc-HYNIC-siRNA(negative control group) were 1.286±0.189, 1.348±0.204 and 1.354±0.238, with 99mTcO4- group 1.317±0.164, 1.322±0.159 and 1.401±0.145 respectively, and there were statistically significant differences in different groups at every time spots. The ratios of T/M in 99mTcO4- group and 99mTc-HYNIC-siRNA(negative control group) were significantly lower than those in 99mTc-HYNIC-siRNA(interference group) at 1, 4, 10 h respectively(tcontrol=29.20, 33.84 and 38.07, 99mTcO4-=31.29, 37.61 and 41.86, all P<0.01), and the T/M ratios at 1 h, 4 h, 10 h of 99mTc-HYNIC-siRNA(negative control group) and 99mTcO4- groups were not significantly different(t=0.392, 0.318 and 0.533, all P>0.05). Conclusions: The 99mTc-HYNIC-siRNA(interference group) could specificity accumulated in breast cancer tissue. The imaging with 99mTc-HYNIC-siRNA may be a promising method for diagnosis of breast cancer.
		2017 Vol. 28 (5): 363-367 [Abstract] ( 867 ) HTML (1 KB) PDF (0 KB) ( 176 )

	368	Prenatal imaging diagnosis and prognosis of fetal cerebral ventriculomegaly
		YANG Wu-bo, ZHANG Jun
		The fetal cerebral ventriculomegaly is the most common central nervous system abnormality. Fetuses with ventriculomegaly can be detected at early stage by prenatal ultrasonography. Ultrasound can dynamically monitor the width of fetal lateral ventricle. Magnetic resonance imaging has various clinical value and significance for evaluation the development of the fetal brain. As a necessary complement to ultrasound, MRI is used not only to determine the expansion degree, to find the cause and associated abnormalities, but also to evaluate the prognosis after birth. The prognosis of fetal lateral ventricle enlargement varies considerably. While isolated mild ventriculomegaly has better prognosis in which lateral ventricle width <12 mm. For incompletely back to normal of the lateral ventricle in uterus, fetus should be paid attention to long-term follow-up after birth.
		2017 Vol. 28 (5): 368-371 [Abstract] ( 787 ) HTML (1 KB) PDF (0 KB) ( 115 )

	372	Quantitative evaluation of the subarachnoid space at the trigeminal nerve root entry zone by#br# MRI in patients with trigeminal neuralgia
		CHEN Cheng1, ZHENG Lu2, LI Ya-bin2, ZHANG Qian-sheng2, CHU Yan-fei2, YAO Zhi-qiang2,

		2017 Vol. 28 (5): 372-373 [Abstract] ( 766 ) HTML (1 KB) PDF (0 KB) ( 227 )

	374	Application of ultrasound in diagnosis of female stress urinary incontinence by observing urethral rotation angle
		XIAO Ting, ZHANG Xin-ling, YANG Li-xin, MAO Yong-jiang, HUANG Ze-ping, GAN Yi-xin

		2017 Vol. 28 (5): 374-375 [Abstract] ( 891 ) HTML (1 KB) PDF (0 KB) ( 186 )

	376	Infratentorial papillary meningioma: report of one case
		MA Zhen, CHENG Jing-liang, ZHANG Yong, WANG Wei-jian, REN Qi

		2017 Vol. 28 (5): 376-377 [Abstract] ( 745 ) HTML (1 KB) PDF (0 KB) ( 177 )

	377	Primary yolk sac tumor of saddle area: report of one case
		XU Ke, ZHANG Yong, CHENG Jing-liang, WANG Wei-jian

		2017 Vol. 28 (5): 377-378 [Abstract] ( 661 ) HTML (1 KB) PDF (0 KB) ( 136 )

	378	Pleomorphic undifferentiated sarcoma of the kidney: report of one case
		HUANG Jia-yi, CHEN Long, TAN Zhen, ZHONG Xing

		2017 Vol. 28 (5): 378-379 [Abstract] ( 757 ) HTML (1 KB) PDF (0 KB) ( 153 )

	380	Cystic adult Wilms’ tumor complicated urinary fistula: report of one case
		DENG Xi-jia, LIU Ai-lian, CHEN Li-hua, ZHANG Li-zhi, KONG Jie-nan

		2017 Vol. 28 (5): 380-380 [Abstract] ( 555 ) HTML (1 KB) PDF (0 KB) ( 258 )

Copyright © Editorial Board of JOURNAL OF CHINA MEDICAL IMAGING
Supported by:Beijing Magtech