Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma
YE Jing1, XU Yi-kai1, LIU Xian2, LU Xue-song1, XU Peng-jun1, HUANG Qi-liu1, JIANG Zhi-qiang1, LV Guo-shi1
1. Nanfang Hospital, Nanfang Medical University, Guangzhou 510515;2. Department of Radiology, Guangdong Province Traditional Chinese Medicine Hospital, Guangzhou 510102, China
Abstract：Objective: To investigate MR enhancement of different administration routes in MR pretargeting immunology imaging. Methods: Two groups of mice were injected with SA-DTPA-Gd through tail vein(iv) and intra-peritoneal cavity(ip) respectively, and the MR signal intensity of tumor and liver was determined. Result: In iv group and ip group the maximum enhancement rate of tumor was 70.2% and 46.4% respectively, and there was significant difference. The maximum enhancement rate of liver was 23.7% in ip group and 20.4% in iv group, and there was no signifinant difference. Conclusion: Intravenous injection is in favor of SA-DTPA-Gd’s accumlation in tumor than intraperitoneal injection, and a more homogenious intratumoral distribution is archived.
叶 靖;许乙凯;刘 岘;陆雪松;许鹏君;黄其鎏;蒋志强;吕国士. SA-DTPA-Gd经腹腔和静脉给药后荷人结肠癌裸鼠的MR增强对比研究[J]. , 2006, 17(3): 167-170.
YE Jing;XU Yi-kai;LIU Xian;LU Xue-song;XU Peng-jun;HUANG Qi-liu;JIANG Zhi-qiang;LV Guo-shi. Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma. , 2006, 17(3): 167-170.
2006, Vol. 17 
