Abstract：Objective: To study the hemodynamic changes of ophthalmic artery(OA), short posterior ciliary artery(SPCA), and central retinal artery(CRA) in patients with myopia. Methods: Fifty-two eyes in 26 patients with medium myopia, 44 eyes of 23 patients with severe myopia, and 50 eyes of 25 normal subjects were studied. Peak systolic velocity(PSV), end diastolic velocity(EDV) and resistance index(Rl) of OA, SPCA and CRA were measured in the 3 groups and comparison was carried out. Results: Compared to normal subjects, the patients with medium myopia and severe myopia showed a significant decrease(P<0.05) in the mean PSV and EDV of the CRA and SPCA, and a significant increase(P<0.05) in the mean RI of the CRA and the PCA, but there was no significant difference(P>0.05) in the OA for the 3 groups. Compared to the patients with medium myopia, the patients with severe myopia showed a significant decrease(P<0.05) in the mean PSV and EDV of the CRA and SPCA, and a significant increase(P<0.05) in the mean RI of the CRA. Compare to normal subjects, eye axes and eye pressure in myopia patients also showed a significant difference(P<0.05). Conclusion: In patients with myopia, there appears to be an association between decreased mean flow velocity and an increased mean resistive index in the ocular vasculature. Factors relating to both vasculature and eye pressure have an important role in the pathogenesis of myopia.
2006, Vol. 17 
