Abstract:Objective: To assess the role of magnetic source imaging combined with Gamma knife for treating refractory epilepsy. Methods: To localize the epileptic focus by magnetic source imaging and as a guidance for Gamma knife for treating refractory epilepsy in 8 patients. Results: According to the standard of effect made by Nanjing Army General Hospital, the result was satisfied in 3 cases(37.5%), improved significantly in 3 cases(37.5%), good result in 1 case(12.5%), 1 of the 8 cases got bad curative effect(12.5%). No patients experienced Gamma knife-related complications. Conclusion: Magnetic source imaging could localize the epileptic focus precisely and non-invasively. The epileptic focus could be treated by Gamma knife according to the magnetic source imaging localization.