Abstract：Objective: To evaluate the significance of 99Tcm-HMPAO－SPECT in clinical evaluation of glioma. Methods: Seventy-two patients with primary glioma confirmed by pathology underwent 99Tcm-HMPAO and MRI. The uptake of 99Tcm-HMPAO was semi-quantified by tumor cerebellum index(TCI). In light of WHO classification system, these cases included 33 low-grade and 39 high-grade gliomas. Tumor MRI parameters i.e. enhancement, necrosis and edema were evaluated as three grades. Results: The relationships among 99Tcm-HMPAO uptake index and tumor histological grade and MRI characteristics were evaluated respectively. In the high-grade tumor group, 32.6% had a high uptake of 99Tcm-HMPAO(TCI>1.0). 55.8% low uptake(TCI<0.8), and 11.6% moderate uptake similar to normal brain tissue(TCI:0.8~1.0) In low-grade group, these ratios were 10.3%, 27.6% and 62.1% respectively. The difference between the two groups is significant. Both tumor necrosis and edema had a significant influrence on uptake of 99Tcm-HMPAO. Conclusions: The modification of rCBF in low-grade glioma is usually similar to normal brain tissue, but in high-grade lesion it is great. Tumor necrosis and edema are two factors in relation to low rCBF.
2007, Vol. 18 
