1. Department of Radiology, Affiliated Taizhou People’s Hospital of Nantong University, Taizhou Jiangsu 225300, China;2. Department of Medical Image Engineering, Medical School of Nantong University, Nantong Jiangsu 226001, China
Abstract：Objective: To investigate the abnormal region of gray matter and its’ distribution in Parkinson’s disease(PD) patients using voxel-based morphometry(VBM) method. Method: Twenty-five cases of clinically defined PD patients and 23 cases of healthy controls received MR scan on 3.0T MR system. The T1WI data were collected. Using VBM method to compare the images of brain gray matter between two groups. The results were shown by statistical parametric mapping. Result: PD patients showed extensively decreased gray matter volume in widespread brain regions involving bilateral insular, parahippocampal gyrus, amygdale and right frontal, temporal, occipital, parietal lobes and left medial frontal gyrus. Conclusion: The VBM could thoroughly and accurately reflect the abnormal area of brain gray matter quantitatively which were common in PD patients, and it also provided the necessary neural imaging evidence for the pathological mechanism of PD patients with multiple system involvement.
2014, Vol. 25 
