Abstract： In recent years, amide proton transfer(APT) imaging, as a new modality of MR imaging, has attracted more and more attention in clinical applications. APT imaging can detect the exchange characteristics of amide protons in free proteins and peptides and water protons by means of water signal changes. APT imaging can reflect tumor, stroke, neonatal hypoxic-ischemic encephalopathy related to protein and pH at the molecular level. In addition to the nervous system, APT imaging has now been used in several other systems. APT imaging, as an in vivo, noninvasive, cellular and molecular level MR imaging modality without exogenous contrast agents, can provide more information for clinical studies and will be further developed in future studies.
王晓明，郑 阳. 酰胺质子转移成像的临床应用及挑战[J]. 中国临床医学影像杂志, 2017, 28(10): 692-696.
WANG Xiao-ming, ZHENG Yang. Clinical application and challenges of amide proton transfer imaging. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(10): 692-696.
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