Abstract：Objective: To evaluate the value of interictal PET and ictal SPECT brain imaging in localizing the foci of intractable epilepsy in children. Methods: Thirty pediatric patients with intractable epilepsy were performed with interictal PET and ictal SPECT brain imaging. The results were compared and analysed. Results: In interictal PET, 16 patients showed local single lobe hypo-metabolism, multi-lobe and diffuse hypo-metalism in 14 patients. During ictal SPECT studies, 18 showed hyper-perfusion in solitary lobe, multi-hyper-perfusion foci in 10 patients. Compared the two examinations, 26(86.7%) were accorded with each other in 30 patients. Of the 12 patients with multiple and diffuse hypometabolism in interictal PET, 6 patients showed foci changed to solitary focal hyper-perfusion in ictal SPECT. Conclusion: Interictal PET combined with ictal SPECT can learn from others’s strong points to offset one’s weakness, elevate the accuracy in localizing epileptic foci, offer more reliable messages for treatment.
2006, Vol. 17 
