Abstract:Objective: To investigate the diagnostic value of PET/CT with fluorine-18-labeled fluorodeoxyglucose(FDG) for primary small intestine tumors. Method: 18F-FDG PET/CT imaging findings were retrospectively analyzed in 38 cases with the small intestine diseases, of which 37 cases were proved by pathology after operation or biopsy and one case was confirmed after a 3-year follow-up. The images were interpreted and compared with the histopathologic findings to assess the value of 18F-FDG PET/CT in detecting primary small intestinal malignant tumors. Results: Among 38 patients, 33 cases had high FDG uptake, 87.9%(29/33) of which were small intestinal malignant tumors. There was no statistical significance in SUVmax value between malignant neoplasms and benign lesions. The main manifestations of small intestinal tumors were focal thickening of intestines and soft tissue masses on CT images. Three cases were false positive and one case was false negative. The sensitivity, specificity, diagnostic accuracy, false positive rate and false negative rate of 18F-FDG PET/CT were 96.8%, 57.1%, 89.5%, 42.9% and 3.2%, respectively. Conclusion: 18F-FDG PET/CT was of great value for the diagnosis of primary small intestinal tumors.However, the benign lesions with high uptake and the malignant lesions with low uptake were easy to be misdiagnosed, demanding more attention for diagnosis.