Abstract：Objective: To analyze the collaborative application value of 18F-FDG PET/CT in CT guided lung percutaneous needle biopsy. Methods: A retrospective analysis of 22 patients who underwent both 18F-FDG PET/CT checking and CT-guided chest percutaneous puncture biopsy from 2013 to 2014 was done. The lung puncture target was mainly selected according to 18F-FDG PET/CT imaging. All of the cases received multi-slice spiral CT guided percutaneous lung puncture biopsy, surface located by grid markers. Combined with pathological and follow-up results, the collaborative diagnostic value of 18F-FDG PET/CT accumulations for pinpointing the best location in CT guided percutaneous lung puncture biopsy was studied. Results: 40.9%(9/22) of the high uptake area of lesions were located on the edge or eccentric place, and puncture target spot was adjusted correspondingly. All of the 22 cases of biopsy were performed one time successfuly. The complications were slight pneumothorax in 3 cases and little pulmonary hemorrhage in 6 cases, without hemoptysis. There were 13 cases of adenocarcinoma, 5 cases of squamous cell carcinoma, 1 case of small cell carcinoma, 2 cases of inflammatory granuloma, and 1 case of fungal infection. Compared with the postoperative and long-term follow-up, only one case of lung cancer was misdiagnosed as inflammatory pseudotumor. The accuracy rate of single percutaneous lung puncture biopsy was 95.65%. The positive predictive value and negative predictive value, sensitivity, specificity were 100%, 66.7%, 95%, 100%, respectively. Conclusion: 18F-FDG PET/CT image can help to select the target of percutaneous lung biopsy, and to improve the accuracy of biopsy, which has important clinical value.
2015, Vol. 26 
