Abstract：Objective: The aim of this study was to investigate whether metabolic tumor volume(MTV) and total lesion glycolysis(TLG) of primary tumor could give a prediction of the sensitivity in non-small cell lung cancer chemotherapy. Method: Eighteen cases with phase Ⅲ~Ⅳ non-small cell lung cancer patients were reviewed retrospectively, who received platinum-based first-line chemotherapy and had 18F-FDG PET/CT examinations both before and after therapy. MTV and TLG were determined with two thresholds which were 30% SUVmax and 50% SUVmax, using PERCIST criteria to evaluate outcome. Statistical analysis included rank-sum test and ROC curve. Results: The change rates of indicators including ΔTLG30% SUVmax(u=73, P=0.003), ΔMTV30% SUVmax(u=73, P=0.003), ΔTLG50% SUVmax(u=65, P=0.025), ΔMTV50% SUVmax(u=65, P=0.025) and ΔSUVmax(u=74, P=0.003) were statistically significant. According to ROC curve, change rates of TLG and MTV were 62.2% and 56.3% respectively could discriminate sensitivity to chemotherapy with threshold of 30% SUVmax, as well as 68.9% and 63.3% with threshold of 50% SUVmax. Conclusions: The change rates of TLG and MTV of primary tumor in non-small cell lung cancer patients can contribute to filtering out chemotherapy sensitivity.
陈美洁;李 娜;杜补林;李亚明. 非小细胞肺癌患者原发病灶的糖代谢与化疗疗效的关系：一个以PERCIST为评价标准的初步研究[J]. , 2015, 26(3): 166-169.
CHEN Mei-jie;LI Na;DU Bu-lin;LI Ya-ming. The relationship between primary lesion glucose metabolism of NSCLC andchemotherapy: a preliminary study according to PERCIST criteria. , 2015, 26(3): 166-169.
2015, Vol. 26 
