Correlative study of VEGF, bFGF and angiogenesis with MSCT multi-phase scanfeatures of benign prostatic hyperplasia
LIU Jin-gang1, WANG Bin1, NIU Qing-liang2, WANG Xi-zhen1, DU Han-wang1
1. Medical Imaging Center, Affiliated Hospital of Weifang Medical College, Weifang Shandong 261031, China;2. Medical Imaging Center, Weifang Hospital of Traditional Chinese Medicine, Weifang Shandong 261041, China
Abstract：Objective: To investigate the correlation of the expression of vascular endothelial growth factor(VEGF), basic fibroblast growth factor(bFGF) and angiogenesis with MSCT features of benign prostate hyperplasia(BPH). Materials and Methods: Thirty-five BPH cases proved by histopathology were examined with multi-phase contrast-enhanced MSCT scanning. Each pathologic specimen was stained with hemetoxylin and eosin and immunohistochemical technique to detect the level of MVD, VEGF, bFGF and related microvascular indexes. The CT features and the expression of MVD, VEGF, bFGF were analyzed to investigate the relationship with each other. Result: The peak value of 71.43%(25/35) BPH was seen in delayed phase(180s), 28.57%(10/35) in venous phase(75s). The positive rate of VEGF and bFGF was 31.43%(11/35) and 14.29%(5/35) respectively. There was significant positive correlation between VEGF, bFGF and MVD(P<0.01), and between MAV and MVD, VEGF, bFGF(P<0.01), between VEGF and bFGF(P<0.01), and negative correlation of MAV with average diameter, perimeter and area. There was no correlation between MAV and heterotypic index(P>0.01). Conclusion: The expression of bFGF, VEGF and MVD in BPH was different. The MSCT multi-phase scan features of BPH have significant correlation with the expression of VEGF, bFGF and angiogenesis.
2008, Vol. 19 
