Research on BMD measurement of femoral neck with no-external reference phantom CAD based on QCT data
PAN Shi-nong1, ZHAO Heng1, ZHAO Kai2, LIAO Wei1, KANG Yan2, GUO Qi-yong1
1. Department of Radiology, the Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China;2. Sino-Dutch Biomedical and Information Engineering School of Northeastern University, Shenyang 110004, China
Abstract：Objective: To study the values of bone mineral density(BMD) measurement of femoral neck with and without external reference phantom computer-aided detection(CAD) based on QCT data, and DXA, in order to accurately and conveniently study BMD and set up large sample BMD database. Materials and Methods: Volumetric CT scanning(64-slice CT, Philips) of femoral neck were initially performed with external reference phantom(approved by Ethics Committee in our hospital) in 53 health-volunteers(10 men, 43 women, 38~70 years, mean 57 years), scanning ranging from L5 to femoral neck, and then did DXA examination. Doing BMD measurement of femoral neck without external reference phantom with OsteoCAD1.2 software. Medial vastus muscle(MVM) and subcutaneous fat, lateral vastus muscle(LVM) and subcutaneous fat, erector spinae(ES) and subcutaneous fat respectively were determined as internal references. Linear Regression correlation analysis was made by SPSS 10. Results: The correlation of integral, trabecular, cortical BMD measured with and without external reference phantom CAD, DXA were at a high level of significance. The correlation coefficients of integral, cortical, trabecular BMD selected MVM as internal references and that with external reference phantom were 0.956, 0.904, 0.974 respectively. The correlation coefficients of integral, cortical, trabecular BMD selected LVM as internal references and that with external reference phantom were 0.943, 0.870, 0.967 respectively. The correlation coefficients of integral, cortical, trabecular BMD selected ES as internal references and that with external reference phantom were 0.955, 0.886, 0.976 respectively. The correlation coefficients of DXA and trabecular BMD without external reference phantom in MVM, LVM, ES as internal references were 0.911, 0.868, 0.906 respectively. Conclusion: BMD measurement of femoral neck without external reference phantom based on QCT data is an effective and feasible method, both MVM and LVM selected as internal reference is more convenient and has no difference comparing with erector spinae as internal reference.
2009, Vol. 20 
