Abstract：Objective: To compare the diagnostic value of 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy for the detection of bone metastases in patients with lung cancer. Methods: We examined 49 patients, 28 men, 21 women with lung cancer, mean age (58.9±10.8)years. All patients underwent both whole-body 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy within 10 days. Bone metastases were verified either by pathological results or MR findings or follow-up more than half a year. Results: Bone metastases were confirmed in 228 of the 259 foci. The sensitivity for bone metastases using 18F-FDG PET-CT and 99mTc-MDP as 90.8% and 56.6% respectively, the specificity was 93.5% and 45.2% respectively. The accuracy was 91.1% and 55.2% respectively. Conclusion: The specificity and the overall accuracy of 18F-FDG PET-CT for the diagnosis of bone metastases in patients with lung cancer are higher than those of 99mTc-MDP bone scintigraphy.
2009, Vol. 20 
