Abstract：Objective: To improve the understanding concerning CT initial manifestations and changing course of invasive pulmonary aspergillosis(IPA). Methods: One hundred and forty-one serial CT scans(mean, 6.4) in 22 consecutive patients were reviewed retrospectively over a median follow-up of 96 days(20~692 days), number and size of lesions and CT manifestations of IPA were evaluated dynamically. Results: On CT initial imaging, multiple lesions usually were observed, median lesion number and size were 5.3(1~20) and 1.39cm(0.3~3.7cm) respectively. An accompanying halo sign was early characteristic CT signs of IPA and was observed in 77.3%(17/22) patients at the initial CT scans. During 7~14 days follow-up, both number and size of lesions showed increase, 5.8(1~23) and 1.64cm(0.4~4.2cm) respectively. The strongest predictive diagnosis of IPA was the formation of the air crescent sign and cavitation that evolved at a median 23 days. Conclusion: IPA mostly occurred in immunocompromised patients, An accompanying halo sign around nodes was early characteristic CT signs of IPA, familiar with its CT manifestations and changing course have an important significance in diagnosis and estimating prognosis.
2009, Vol. 20 
