CT perfusion imaging in studying the relationship between permeability surface and secondary hemorrhage inacute cerebral infarction: an experimental study
QUAN Guan-min, YUAN Tao, LEI Jian-ming, LI Shun-ji, YANG Jie, CAO Zhi-yong, LIU Huai-jun
Department of Radiology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Abstract：Objective: To investigate the correlation between permeability surface(PS) parameters from multislice CT perfusion imaging(CTP) and hemorrhagic transformation(HT) after acute experimental cerebral infarction. Methods: Autologous thrombus was injected into unilateral internal carotid arteries of 75 rabbits to set up acute cerebral infarction model. When infarction was comfirmed by MR imaging at 3 hours after operation, CTP in coronal plane was made from 3h to 72h after cerebral infarction. PS images were calculated at workstation by using software of Perfusion 3. The HT of cerebral infarct animals were classified into hemorrhagic infarction(HI) group and parenchymal hematoma(PH) group according to the method of European-Australasian acute stroke study(ECASS). The difference between the PS value of non-HT and various HT, and the Spearman correlation between PS and the degree of HT were assessed by using SPSS 11.5 software. Results: Cerebral ischemic model was successfully set up in 59 rabbits(78.67%). No pathologic findings of HT was found in 21 animals(35.59%, 21/59). Thirty-eight rabbits(64.41%, 38/59) which had HT included 31 rabbits(52.54%, 31/59) with HI and 7(11.87%, 7/59) with PH. After the peak of infarction lesions at 3h, PS decreased gradually. There was significant difference between the PS value of non-HT and HT groups at every time point(P=0.000~0.010) except at 24h(P=0.093). PS values of PH group were higher than that of HI rabbits from 3h to 12h(P=0.019~0.030), whereas there was no obvious difference between them from 24h to 72h(P>0.05). There was obvious correlation between PS and HT at 6h, 12h, 48h and 72h with the Spearman correlation from 0.718 to 0.805(P=0.004~0.000). Only moderate correlation was found between 3h and 24h, with the Spearman correlation of 0.564 and 0.553(P=0.000 and P=0.014). Conclusion: PS of acute cerebral infarction has considerable correlation with HT, probably because of the prominent disruption of microvascular structure of the HT group.
2008, Vol. 19 
