Abstract：Objective: To study the increase and decrease of MR signal in the functional cortical regions related to the vestibular vertigo with caloric stimulation, 0℃ water, using blood-oxygen level dependent functional MRI(BOLD-fMRI) technique. Materials and Methods: Twenty right-handed human volunteers, 12 males and 8 females, age from 25 to 39 years old, had nothing wrong with the hearing ability and the cavity of the middle ear after the otoscopic examination, the pure-tone audiometry and the tympanometry tests. They were all examined with a recording electronystagmograph before the fMRI scan to confirm that the caloric stimulus actually induced vestibular vertigo and nystagmus. During the electronystagmograph test, 15ml ice water(0℃) was injected into the right ear of each volunteer within 15s with the subject’s eyes open. The functional images of brain were acquired with a 1.5T Signa Infinity Twin+Excite MR system of GE Co. All the subjects were blindfolded with eyes open in a dark circumstance. All data were analyzed on single-subject level and group level using SPM 99. Result: Several cortical and subcortical regions were activated and deactivated. The activated regions included: the supplementary motor area, paracentral lobule, left precuneus lobe, left posterior insula, left MT/MST complex, the cingulum gyrus, left occipital lobe(BA19) and left cerebellum. The deactivated regions included: bilateral superior and middle frontal gyri, right precentral gyrus(BA2/3), left precuneus lobe, right MT/MST. Conclusion: Cold water stimulation at 0℃ in fMRI confirms a widespread cortical network involved in vestibular signal processing.
王 志;陈 敏;龚 霞;黄魏宁;徐 亮;周 诚. 冰水刺激诱发前庭性眩晕的功能磁共振研究[J]. , 2009, 20(7): 530-534.
WANG Zhi;CHEN Min;GONG Xia;HUANG Wei-ning;XU Liang;ZHOU Cheng. The fMRI research of the vestibular vertigo induced by the ice-water. , 2009, 20(7): 530-534.
2009, Vol. 20 
