Abstract：Objective: To study the relationship between the CT manifestation of the TN-staging and the expressions of p53 protein in thoracic esophageal carcinoma. Methods: p53 protein expressions in esophageal carcinoma and its relationship with the TN-staging by CT were analyzed by means of SP immunohistochemical technique and CT scanning in 66 patients with esophageal carcinoma proved by pathology. Results: There were 3 cases staged as T1, 10 cases as T2, 41 cases as T3, and 12 cases as T4 by CT. Twenty-one cases were detected to have lymph nodes metastases. The positive-expression rate of p53 protein was 62.12%(41/66). The positive-expression rate of p53 protein in T4-stage was remarkably higher than that in T1~2 and T3-stage(χ2=3.412, P＜0.05, and χ2=3.381, P＜0.05). The positive-expression rate of p53 protein in cases with and without lymph nodes metastasis was 80.95%(17/21) and 37.78%(17/45) respectively, their difference was statistically significant(χ2=10.686, P=0.001). The high expression rate of p53 protein in group T1~2, T3 and T4 was 23.08%(3/13), 46.34%(19/41), 66.67%(8/12) respectively. The expression intensity of p53 protein was increasing in accordance with the rise of T-staging(rs=0.270, P=0.028). The positive-expression rate of p53 protein in cases with lymph nodes metastases(short axis diameter≤2cm) was 84.62%(11/13), in mediastinal lymph nodes metastases(short axis diameter＞2cm) was 75.00%(6/8). Their difference was not statistically significant(P=0.289). Conclusion: The high expressions of p53 protein were correlated to CT TN-staging. The expression intensity of p53 protein is increasing in accordance with the rise of T-staging. There was no correlation between the size of lymph nodes metastases and the expressions of p53 protein.
许建生;黄伟鹏;陈洁容;姚沛旭;陈卫鹏. 胸段食管癌TN分期的CT表现与p53蛋白的关系[J]. , 2009, 20(7): 527-529.
XU Jian-sheng;HUANG Wei-peng;CHEN Jie-rong;YAO Pei-xu;CHEN Wei-peng. The relationship between p53 protein and CT manifestation of the TN-staging in thoracic esophageal carcinoma. , 2009, 20(7): 527-529.
2009, Vol. 20 
