Correlation between cystic necrosis of cranio-hemangiopericytoma and the expression of P73
WEI Xiao-hui1, ZHOU Jun-lin2, LI Wei-ping3, DONG Chi2
1.Department of CT, the First People’s Hospital of Lanzhou, Lanzhou 730050, China;2.The Second Hospital of Lanzhou University, Lanzhou 730030, China;3.Department of Pathology, the Basic Medical College of Lanzhou University, Lanzhou 730000, China
Abstract：Objective: To investigate the correlation between cystic necrosis and P73 protein expression in cerebral hemangiopericytoma. Methods: Twenty-nine cases with intracranial hemangiopericytoma were chosen, 25 cases of angiomatous type meningioma were also enrolled as control group. All cystic or necrotic signs on MRI of the two tumors were analyzed, which were scored according to Asari’s method. P73 protein expressions were detected by S-P immunohistochemical method. Results: Twenty-nine cases showed positive expression, and there was significant difference in the expression of P73 between intracranial hemangiopericytoma and angiomatous type meningioma(P<0.01). The positive expression of P73 protein increased with increasing of cystic or necrotic signs on MRI of intracranial hemangiopericytoma(P<0.05). Conclusions: Cystic or necrotic sign on MRI was closely related to the high expression of P73 protein in intracranial hemangiopericytoma, which can been used as reference information evaluating the treatment and prognosis of intracranial hemangiopericytoma.
2010, Vol. 21 
