Experimental research of 99mTc-H-Annexin V scintigraphy in evaluating the degree ofpathological changes of atherosclerotic lesions in rabbit
SONG Li-ping1, HUA Zi-chun2, ZHANG Xin1, XUAN Nan1, XING Hai-yan1
1.Department of Nuclear Medicine, the First Affiliated Hospital, Liaoning Medical College, Jinzhou Liaoning 121000, China;2.State Key Laboratory of Medical Biology Technology, Nanjing University, Nanjing 210093, China
摘要目的:探讨99mTc标记的重组改良型人膜联蛋白(H-Annexin V)评估兔动脉粥样硬化病变程度的价值。方法:9只雄性大耳白兔随机分为球囊损伤组、单纯高脂饲料组、正常对照组,每组3只。球囊损伤组兔通过球囊损伤腹主动脉内膜,并饲喂高脂饲料15周。单纯高脂饲料组兔饲喂高脂饲料15周。对照组兔给予普通饲料喂养15周。15周后3组大白兔均自耳缘静脉注射99mTc-H-Annexin V 37~55.5MBq/kg,进行活体及离体血管显像。对球囊损伤组和高脂饲料组兔降主动脉分段,测定各段质量和放射性计数,并进行病理学检查。结果:显像剂注射后2小时,球囊损伤组兔降主动脉显影最为清晰。单纯高脂饲料组兔仍可见降主动脉影像。对照组兔降主动脉显影不明显。注射显像剂后2小时球囊损伤组靶/非靶(T/NT)比值(2.68±0.25)明显高于单纯高脂饲料组(2.08±0.18,t=3.26,P<0.05)和正常对照组(1.57±0.24,t=5.44,P<0.01)。离体显像可见:球囊损伤组影像较为清晰,而单纯高脂饲料组可见降主动脉显影,但影像欠清晰。球囊损伤组含AS斑块的血管片段放射性摄取为63.33±14.11cpm/mg,明显高于单纯高脂饲料组含AS斑块血管片段的放射性摄取52.08±12.39cpm/mg(t=2.17,P<0.05)。结论:99mTc-H-Annexin V核素显像在评估兔动脉粥样硬化病变程度方面具有重要的临床价值。
宋丽萍;华子春;张 欣;轩 楠;邢海燕. 应用重组改良型人膜联蛋白评估兔动脉粥样硬化病变程度的实验研究[J]. , 2010, 21(5): 358-360.
SONG Li-ping;HUA Zi-chun;ZHANG Xin;XUAN Nan;XING Hai-yan. Experimental research of 99mTc-H-Annexin V scintigraphy in evaluating the degree ofpathological changes of atherosclerotic lesions in rabbit. , 2010, 21(5): 358-360.